肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2010年
7期
486-487,490
,共3页
肝肿瘤%复发%α-L岩藻糖苷酶%甲胎蛋白%诊断
肝腫瘤%複髮%α-L巖藻糖苷酶%甲胎蛋白%診斷
간종류%복발%α-L암조당감매%갑태단백%진단
Liver neoplasms%Recurrence%Alpha-L-fucosidese%Alpha-fetoproteins%Diagnosis
目的 探讨联合检测血清中α-L岩藻糖苷酶(AFU)和甲胎蛋白(AFP)在预测肝癌术后复发的价值.方法 按术后复发组、术后未复发组和健康对照组分3组检测血清AFU、AFP水平,AFU检测采用比色速率法,设定AFU>40U/L为阳性;AFP检测采用化学发光免疫法,设定AFP>13.6μg/L为阳性.结果 术后复发组与术后未复发组、健康对照组比较,AFU、AFP水平差异有统计学意义(P<0.001);AFU、AFP水平在术后未复发组较健康对照组高,但差异无统计学意义(P>0.05).术后复发组肝癌复发前后AFU、AFP差异有统计学意义(P<0.001).AFU+AFP联合检测与AFU、AFP单独检测相比敏感度、准确度差异有统计学意义(P<0.001),但AFU与AFP相比差异无统计学意义(P>0.05);AFU+AFP、AFU、AFP三者特异度比较,差异无统计学意义(P>0.05).结论 联合检测血清中AFU、AFP水平,可显著提高肝癌术后复发的诊断率,并可作为预测肝癌术后复发的检测指标.
目的 探討聯閤檢測血清中α-L巖藻糖苷酶(AFU)和甲胎蛋白(AFP)在預測肝癌術後複髮的價值.方法 按術後複髮組、術後未複髮組和健康對照組分3組檢測血清AFU、AFP水平,AFU檢測採用比色速率法,設定AFU>40U/L為暘性;AFP檢測採用化學髮光免疫法,設定AFP>13.6μg/L為暘性.結果 術後複髮組與術後未複髮組、健康對照組比較,AFU、AFP水平差異有統計學意義(P<0.001);AFU、AFP水平在術後未複髮組較健康對照組高,但差異無統計學意義(P>0.05).術後複髮組肝癌複髮前後AFU、AFP差異有統計學意義(P<0.001).AFU+AFP聯閤檢測與AFU、AFP單獨檢測相比敏感度、準確度差異有統計學意義(P<0.001),但AFU與AFP相比差異無統計學意義(P>0.05);AFU+AFP、AFU、AFP三者特異度比較,差異無統計學意義(P>0.05).結論 聯閤檢測血清中AFU、AFP水平,可顯著提高肝癌術後複髮的診斷率,併可作為預測肝癌術後複髮的檢測指標.
목적 탐토연합검측혈청중α-L암조당감매(AFU)화갑태단백(AFP)재예측간암술후복발적개치.방법 안술후복발조、술후미복발조화건강대조조분3조검측혈청AFU、AFP수평,AFU검측채용비색속솔법,설정AFU>40U/L위양성;AFP검측채용화학발광면역법,설정AFP>13.6μg/L위양성.결과 술후복발조여술후미복발조、건강대조조비교,AFU、AFP수평차이유통계학의의(P<0.001);AFU、AFP수평재술후미복발조교건강대조조고,단차이무통계학의의(P>0.05).술후복발조간암복발전후AFU、AFP차이유통계학의의(P<0.001).AFU+AFP연합검측여AFU、AFP단독검측상비민감도、준학도차이유통계학의의(P<0.001),단AFU여AFP상비차이무통계학의의(P>0.05);AFU+AFP、AFU、AFP삼자특이도비교,차이무통계학의의(P>0.05).결론 연합검측혈청중AFU、AFP수평,가현저제고간암술후복발적진단솔,병가작위예측간암술후복발적검측지표.
Objective To explore the value of the combined detection of serum AFU and AFP on predicting postoperative recurrence of hepatocellular carcinoma. Methods Three groups were classified as pathological observation group, pathological control group and health control group. AFU was detected by ratio colorimetric method with the AFU>40 U/L defined as positive values. AFP was detected by microparticle enzyme immunoassay with AFP> 13.6 μg/L defined as positive values. Results AFU and AFP level of the pathological observation group were significantly different compared with the pathological control group and health control group(P <0.001). AFU and AFP level of the pathological control group were higher than those in the health control group, but no significant difference (P >0.05). For the pathological observation group, the level of AFU and AFP after recurrence were significantly different than that before (P <0.001). As to the sensitivity and accuracy of method, AFU + AFP and AFU or AFP were significantly different (P <0.001). There was no significant difference between AFU and AFP(P >0.05). As to the specificity of method, there was no significant differences among AFU+AFP, AFP and AFU (P >0.05). Conclusion The combined detection of serum AFU and AFP levels significantly raised the diagnostic value of liver cancer recurrence. They may applied as a predictor or indicator of postoperative recurrence of hepatocellular carcinoma.
