CAJ | 학술논문

目的:介绍脑血管支架的国内外治疗研究进展,分析支架置入并发症的原因,并探讨各类脑血管支架与宿主间的生物相容性.方法:应用计算机检索Medline database(1989/20090和中国期刊全文数据库(CNKI:1989/2009),由第一作者按纳入和排除标准,对文献进行筛选,资料收集和质量评价.从脑血管支架置入的治疗进展,支架置入治疗的并发症和脑血管支架的生物相容性3方面进行描述和整理.探讨各种脑血管支架的治疗现状、并发症和生物相容性.结果:总结归纳文献内容,脑血管支架临床应用较多的是颅内支架,由于血管的管径限制支架的直径,不同病变对支架直径的要求不同.支架置入并发症主要有腹膜后血肿,颈动脉窦反应,高灌注综合征,脑血管痉挛和血栓形成.在各种脑血管支架中,金属支架生物相容性较差,聚合物支架、涂层支架和药物支架生物相容性均好于金属支架,能有效的预防支架置入后的再狭窄.结论:脑血管支架置入治疗可作为脑血管病的主要治疗方式之一,在治疗过程中,要根据临床症状不同,进行充足的置入前准备,选择合适的支架类型,严格遵循适应证,避免出现并发症.脑血管支架中的药物支架,聚合物支架的生物相容性较好,其他支架生物相容性有待提高.
목적:개소뇌혈관지가적국내외치료연구진전,분석지가치입병발증적원인,병탐토각류뇌혈관지가여숙주간적생물상용성.방법:응용계산궤검색Medline database(1989/20090화중국기간전문수거고(CNKI:1989/2009),유제일작자안납입화배제표준,대문헌진행사선,자료수집화질량평개.종뇌혈관지가치입적치료진전,지가치입치료적병발증화뇌혈관지가적생물상용성3방면진행묘술화정리.탐토각충뇌혈관지가적치료현상、병발증화생물상용성.결과:총결귀납문헌내용,뇌혈관지가림상응용교다적시로내지가,유우혈관적관경한제지가적직경,불동병변대지가직경적요구불동.지가치입병발증주요유복막후혈종,경동맥두반응,고관주종합정,뇌혈관경련화혈전형성.재각충뇌혈관지가중,금속지가생물상용성교차,취합물지가、도층지가화약물지가생물상용성균호우금속지가,능유효적예방지가치입후적재협착.결론:뇌혈관지가치입치료가작위뇌혈관병적주요치료방식지일,재치료과정중,요근거림상증상불동,진행충족적치입전준비,선택합괄적지가류형,엄격준순괄응증,피면출현병발증.뇌혈관지가중적약물지가,취합물지가적생물상용성교호,기타지가생물상용성유대제고.
OBJECTIVE: To introduce advances of cerebrovascular stent at home and abroad, analyze causes for complications following stenting and explore the biocompatibility of cerebrovascular stent and host.METHODS: A computer-based online search of Medline database (1989/2009) and CNKI (1989/2009) was performed to select related articles. According to inclusion and exclusion criteria, the collected articles were selected and evaluated. The treatment advances, complications, and stent biocompatibility were described and summarized to explore the current status, complication and biocompatibility of various cerebrovascular stents.RESULTS: The content of articles was summarized. Intracranial stent is commonly used in clinic. The diameter of vessels confines diameter of stent, so different diseases have different requirements for diameter of stents. The complications following stenting include retroperitoneal hematoma, carotid sinus, hypertransfusion syndrome, cerebral angio spasm and thrombosis. In various stents, polymer, eluting and drug stents have better biocompatibility compared with metal stent, and can effectively prevent restenosis.CONCLUSION: Cerebrovascutar stenting is one of the treatments for cerebrovascular diseases. During the treatment, sufficient operative preparation, appropriate stent and indication are important to avoid complications. Of various stents, polymer and drug stents have good biocompatibility, and the biocompatibility of other stents requires improvement.