CAJ | 학술논문

目的:探讨宫颈环形电切术(LEEP)在诊治不同级别宫颈上皮内瘤变(CIN)的效果.方法:回顾性分析898例行LEEP手术的宫颈上皮内瘤变患者,观察手术时间、出血量、手术前后组织病理诊断结果变化及高危型人乳头瘤病毒变化,评价LEEP诊断情况及治疗效果.结果:LEEP平均手术时间5.1分钟.术中平均出血量5.6ml,术前电子阴道镜下活检结果与IEEP术后病理结果诊断一致率为77.73%(698/898).LEEP术后病理结果级别升高96例(10.69%),手术前后HPV-DNA负荷量下降明显,差异有统计学意义(P<0.01).结论:LEEP手术对于宫颈病变具有较电子阴道镜下宫颈多点活检更高的宫颈浸润癌检出率,LEEP在切除病变的同时可以有效消除高危型HPV感染,是一种诊断、治疗CIN的非常理想的手段.
목적:탐토궁경배형전절술(LEEP)재진치불동급별궁경상피내류변(CIN)적효과.방법:회고성분석898례행LEEP수술적궁경상피내류변환자,관찰수술시간、출혈량、수술전후조직병리진단결과변화급고위형인유두류병독변화,평개LEEP진단정황급치료효과.결과:LEEP평균수술시간5.1분종.술중평균출혈량5.6ml,술전전자음도경하활검결과여IEEP술후병리결과진단일치솔위77.73%(698/898).LEEP술후병리결과급별승고96례(10.69%),수술전후HPV-DNA부하량하강명현,차이유통계학의의(P<0.01).결론:LEEP수술대우궁경병변구유교전자음도경하궁경다점활검경고적궁경침윤암검출솔,LEEP재절제병변적동시가이유효소제고위형HPV감염,시일충진단、치료CIN적비상이상적수단.
Objective:To evaluate the efficacy of loop electrosurgical excision procedure(LEEP) in the treatment of different grade of cervical intraepithelial neoplasia(CIN). Methods:898 cases with CIN treated by LEEP were retrospectively analyzed. Operation time, blood loss during the operation, changes of histopathologic results and high-rick HPV before and after the operation were studied. The diagnosis and treatment results by LEEP were evaluated. Results: The average operation time was 5.1 minutes. The average blood loss during the operation was 5.6 ml. The concordance rate of pathologic results under colposcope before operation and after LEEP was 77.73% (698/898) .96 cases had increased CIN grade after LEEP(10.69%). The HPV-DNA loading dose after operation declined significantly (P< 0.01). Conclusions: The detection rate of invasive cervical cancer by LEEP is higher than multiple punch biopsy under electronic colposcope. LEEP is an effective method for the diagnosis and treatment of CIN, and it can eliminate high-rick HPV at the same time of ablating the cervical lesion.