CAJ | 학술논문

针对某些原发性肿瘤能够抑制远处转移性肿瘤快速生长的特性,建立转移性肿瘤附近血管内皮细胞迁移运动的二维、三维离散数学模型,对原发性肿瘤分泌的Angiostatin、转移性肿瘤分泌的促血管生成因子(TAF)共同作用下转移性肿瘤内外微血管网的生成过程进行数值模拟.结果表明,原发性肿瘤分泌的血管抑素对转移性肿瘤内外微血管网的生成速度、成熟度及血管分支数量均有明显的抑制作用;可以降低转移性肿瘤的血管化程度,有效抑制转移性肿瘤的快速生长,达到治疗肿瘤的目的;为肿瘤抗血管生成治疗提供有益信息.
침대모사원발성종류능구억제원처전이성종류쾌속생장적특성,건립전이성종류부근혈관내피세포천이운동적이유、삼유리산수학모형,대원발성종류분비적Angiostatin、전이성종류분비적촉혈관생성인자(TAF)공동작용하전이성종류내외미혈관망적생성과정진행수치모의.결과표명,원발성종류분비적혈관억소대전이성종류내외미혈관망적생성속도、성숙도급혈관분지수량균유명현적억제작용;가이강저전이성종류적혈관화정도,유효억제전이성종류적쾌속생장,체도치료종류적목적;위종류항혈관생성치료제공유익신식.
We present 2D and 3D discrete mathematical models for migratory response of endothelial cells inside and outside a metastasic tumor based on a physiological fact that some primary tumor can inhibit metastasic tumor growth quickly. In models we consider inhibitory effects of angiostatin excreted by primary tumor, chemotactic effects of TAF due to metastasic tumor and random movement of endothelial cells and simulate spatiotemporal evolution of microvascular network inside and outside the metastasic tumor. It shows that the angiostatin excreted by primary tumor has obviously inhibitory effects on vascular growth rates, bifurcation amount and development of microvascular network inside and outside the metastasic tumor. Inhibitory effects of angiostatin decrease revascularization of a metastasic tumor and suppress growth of the metastasic tumor in tumor therapy. It provides theoretical references for experimental research on clinical anti-angiogenesis.