CAJ | 학술논문

过去30年,随着工农业的不断发展,由持久性有机污染物(POPs)导致的癌症患者不断增加.目前POPs已广泛存在于水生态系统中,对水生动物的生长发育、种群繁衍、群落结构等产生重要影响.虽然POPs对水生动物的毒理机制非常复杂,但研究表明其毒理机制主要通过芳香烃受体通道(AhR pathway)来进行调控.为全面理解水生动物AhR通道中每一个基因在毒理调控过程中的作用,论文从水生动物芳香烃通道的角度详细阐述了POPs的毒理机制,同时对水生动物中POPs的早期监测进行了讨论,最后提出了未来POPs毒理机制研究的发展方向.
과거30년,수착공농업적불단발전,유지구성유궤오염물(POPs)도치적암증환자불단증가.목전POPs이엄범존재우수생태계통중,대수생동물적생장발육、충군번연、군락결구등산생중요영향.수연POPs대수생동물적독리궤제비상복잡,단연구표명기독리궤제주요통과방향경수체통도(AhR pathway)래진행조공.위전면리해수생동물AhR통도중매일개기인재독리조공과정중적작용,논문종수생동물방향경통도적각도상세천술료POPs적독리궤제,동시대수생동물중POPs적조기감측진행료토론,최후제출료미래POPs독리궤제연구적발전방향.
With the development of industry and agriculture, the case of cancer is incresing gradually in the last thirty years. Considerable part of the cases are caused by persistent organic pollutants (POPs)and some of them belong to the environmental endocrine disruptors. POPs are ubiquitous in the environment, especiUy in the aquatic ecosystem which has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR)pathway in aquatic animals. The overall goal of this review paper is to highlight the toxicological mechanism of AhR pathway that may contribute to a more holistic understanding of each AhR pathway gene behavior in the toxicological process, as well as the early biomonitoring methods of POPs in aquatic animals. Finally, we propose some perspectives for future toxicological mechhanism research of interest.