国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
5期
355-357
,共3页
糖尿病性骨质疏松%晚期糖基化终末产物%骨重建
糖尿病性骨質疏鬆%晚期糖基化終末產物%骨重建
당뇨병성골질소송%만기당기화종말산물%골중건
Diabetic osteoporosis%Advanced glycation end products%Bone remodeling
晚期糖基化终末产物(AGEs)是由蛋白质经非酶催化的Maillard反应所形成,糖尿病时AGEs的形成和积累加速.AGEs与其受体(RAGE)结合后,引起氧化应激及炎性反应,继而导致成骨细胞、破骨细胞及骨髓间充质干细胞功能改变;同时AGEs与骨基质中胶原蛋白交联还可使骨强度下降,是造成糖尿病性骨质疏松的主要原因.检测血清及尿液中的AGEs成分,可作为评估糖尿病患者骨折发生风险的有效指标.
晚期糖基化終末產物(AGEs)是由蛋白質經非酶催化的Maillard反應所形成,糖尿病時AGEs的形成和積纍加速.AGEs與其受體(RAGE)結閤後,引起氧化應激及炎性反應,繼而導緻成骨細胞、破骨細胞及骨髓間充質榦細胞功能改變;同時AGEs與骨基質中膠原蛋白交聯還可使骨彊度下降,是造成糖尿病性骨質疏鬆的主要原因.檢測血清及尿液中的AGEs成分,可作為評估糖尿病患者骨摺髮生風險的有效指標.
만기당기화종말산물(AGEs)시유단백질경비매최화적Maillard반응소형성,당뇨병시AGEs적형성화적루가속.AGEs여기수체(RAGE)결합후,인기양화응격급염성반응,계이도치성골세포、파골세포급골수간충질간세포공능개변;동시AGEs여골기질중효원단백교련환가사골강도하강,시조성당뇨병성골질소송적주요원인.검측혈청급뇨액중적AGEs성분,가작위평고당뇨병환자골절발생풍험적유효지표.
Advanced glycation end products (AGEs) are chemical modifications of proteins by nonenzymatic Maillard reaction.The formation and accumulation of AGEs have been known to be accelerated when suffered from diabetes.Combinations of AGEs and their receptors (RAGE) cause oxidative stress and inflammation,which result in functional alterations of osteoblasts,osteoclasts and bone mesenchymal stem cells.On the other hand,overcrossslinking of AGEs and collagen can also cause loss of flexibility and elasticity and increase brittleness of bone.Accordingly,AGEs play an crucial role in the development of diabetic osteoporosis.Measurement of serum and urinary AGEs composition can be effective for predicting diabetic osteoporosis.