CAJ | 학술논문

目的探讨社交恐怖障碍患者与正常对照组血浆催产素水平差异以及社交恐怖障碍患者血浆催产素水平与症状严重程度、药物疗效的关系.方法 16 ～26岁社交恐怖障碍患者27人,正常对照31人分别接受血浆催产素水平测定,病例组评定社交焦虑量表( Liebowitz Social Anxiety Scale,LSAS)评定症状严重程度,并给予帕罗西汀20 mg/d治疗,治疗第4周评定临床疗效总评量表(Clinical Global Impression Scale,CGI)观察药物疗效.结果非参数检验显示社交恐怖障碍患者血浆催产素水平高于正常对照组[(202.93±145.06)pg/ml,(152.29±101.89)pg/ml],差异具有统计学意义(Z=-1.307,P=0.030).多元线性回归分析显示在社交恐怖障碍患者中,催产素水平是影响社交恐怖障碍严重程度的因素(校正R2=0.158,F=5.888,P=0.023),非条件logistic回归分析显示基线催产素水平是影响帕罗西汀治疗社交恐怖障碍疗效的因素(OR=3.132,P=0.029).结论社交恐怖患者存在血浆催产素水平异常,血浆催产素水平可能是社交恐怖障碍严重程度以及药物疗效的影响因素.
목적 탐토사교공포장애환자여정상대조조혈장최산소수평차이이급사교공포장애환자혈장최산소수평여증상엄중정도、약물료효적관계.방법 16 ～26세사교공포장애환자27인,정상대조31인분별접수혈장최산소수평측정,병례조평정사교초필량표( Liebowitz Social Anxiety Scale,LSAS)평정증상엄중정도,병급여파라서정20 mg/d치료,치료제4주평정림상료효총평량표(Clinical Global Impression Scale,CGI)관찰약물료효.결과 비삼수검험현시사교공포장애환자혈장최산소수평고우정상대조조[(202.93±145.06)pg/ml,(152.29±101.89)pg/ml],차이구유통계학의의(Z=-1.307,P=0.030).다원선성회귀분석현시재사교공포장애환자중,최산소수평시영향사교공포장애엄중정도적인소(교정R2=0.158,F=5.888,P=0.023),비조건logistic회귀분석현시기선최산소수평시영향파라서정치료사교공포장애료효적인소(OR=3.132,P=0.029).결론 사교공포환자존재혈장최산소수평이상,혈장최산소수평가능시사교공포장애엄중정도이급약물료효적영향인소.
Objective To explore the difference of the oxytocin levels between social phobia patients and normal controls,and the relationship of symptoms severity of social phobia with the oxytocin levels and the relationship of drug effects with oxytocin levels.Methods Twenty seven 16-26 years old social phobia patients and thirty one normal controls were tested by an enzyme-linked immunosorbent assay to evaluate the oxytocin levels,and the Liebowitz Social Anxiety Scale was used to evaluate the symptoms severity of social phobia in patient group.Paroxetine was used to treat the patients with the drugs of 20mg per day,the Clinical Global Impression Scale were used to evaluate the drug effects after 4 weeks treatment.Results Mann-Whitney test showed there were significantly differences in oxytocin level between patients and controls ( (202.93 ± 145.06) pg/ml vs ( 152.29 ± 101.89 ) pg/ml,Z =- 1.307,P=0.030).Multiple liner regression analyses showed that the level of oxytocin was an impact factor of the severity of social phobia symptom (adjusted R2 =0.158,F=5.888,P=0.023 ).Logistic regression analyses showed that the level of oxytocin was an impact factor of the effective of drug treatment( OR=3.132,P =0.029 ).Conclusion This study indicate that the value of plasma oxytocin maybe significantly differences between social phobia and normal controls and the plasma oxytocin level maybe a factor which influence the symptoms severity and the effective of drug treatment in social phobia patients.