CAJ | 학술논문

术后复发转移是胃癌患者死亡的主要原因。复发转移的发生主要同肿瘤细胞本身的生物学特性和机体的免疫功能状态有关。近年来发展起来的生物治疗以其靶向性和特异性在许多肿瘤的临床应用中取得了较好的疗效,在治疗胃癌转移复发的临床试验中也取得了一定的疗效。但因胃癌复发转移在临床表现、患者状态及肿瘤特性等方面存在的高度异质性，目前尚无理想的生物治疗策略用于对胃癌复发转移的防治。要使生物治疗成为复发性胃癌的有效防治手段,无论是基础研究还是临床试验，均有许多工作要做。
술후복발전이시위암환자사망적주요원인。복발전이적발생주요동종류세포본신적생물학특성화궤체적면역공능상태유관。근년래발전기래적생물치료이기파향성화특이성재허다종류적림상응용중취득료교호적료효,재치료위암전이복발적림상시험중야취득료일정적료효。단인위암복발전이재림상표현、환자상태급종류특성등방면존재적고도이질성，목전상무이상적생물치료책략용우대위암복발전이적방치。요사생물치료성위복발성위암적유효방치수단,무론시기출연구환시림상시험，균유허다공작요주。
Post-operative recurrence and metastasis remain the leading causes of death for patients with gastric cancer. The major determinants of recurrence and metastasis are the biological characteristics of cancer cells and the immunological status of the patients. In recent years, due to the target-specificity, biotherapy has yielded efficacious responses in diverse clinical applications for cancer treatment, partially for the treatment of recurrence and metastasis of gastric cancer. However, because of the high diversities in clinical manifestations, patients' condition, and tumor's characteristics, there is no ideal strategy of biotherapy established for the prevention and treatment of recurrence and metastasis in gastric cancer. Therefore, a lot of work need to be done in basic research and clinical trial to make the biotherapy effective in treatment of gastric cancer recurrence.