CAJ | 학술논문

目的探讨中国直肠肛门闭锁/狭窄的地理空间分布规律,为病因研究提供线索.方法利用2001-2005年中国出生缺陷监测网以医院为基础在全国对孕28周至产后7 d的围产儿进行监测的数据,采用两维图论聚类分析对全国监测点按直肠肛门闭锁/狭窄的发生率进行空间归类.结果中国直肠肛门闭锁/狭窄总发生率为3.17/万,东部地区发生率高于中、西部,差异有统计学意义(Z值分别为2.50、3.69;P值分别为0.012、＜0.001).全国监测点可聚为6类:第1类监测点主要分布于黑龙江、吉林、辽宁;第Ⅱ类主要分布于福建、广东、海南、广西以及湖南和江西的南部;第Ⅲ类主要分布于北京、天津、河北、山东、江苏和安徽北部;第Ⅳ类主要分布于浙江、上海、安徽、江苏的南部和湖南、江西的北部及湖北、河南、山西、内蒙古;第V类主要分布于宁夏、甘肃、青海;第Ⅵ类主要分布于陕西、四川、重庆、云南、贵州、新疆、西藏.结论聚类结果明确了中国直场肛门闭锁/狭窄的空间分布特征及其规律,对于进一步分析直肠肛门闭锁/狭窄的环境影响因素和区域化监测具有重要的指导意义.
목적 탐토중국직장항문폐쇄/협착적지리공간분포규률,위병인연구제공선색.방법 이용2001-2005년중국출생결함감측망이의원위기출재전국대잉28주지산후7 d적위산인진행감측적수거,채용량유도론취류분석대전국감측점안직장항문폐쇄/협착적발생솔진행공간귀류.결과 중국직장항문폐쇄/협착총발생솔위3.17/만,동부지구발생솔고우중、서부,차이유통계학의의(Z치분별위2.50、3.69;P치분별위0.012、＜0.001).전국감측점가취위6류:제1류감측점주요분포우흑룡강、길림、료녕;제Ⅱ류주요분포우복건、엄동、해남、엄서이급호남화강서적남부;제Ⅲ류주요분포우북경、천진、하북、산동、강소화안휘북부;제Ⅳ류주요분포우절강、상해、안휘、강소적남부화호남、강서적북부급호북、하남、산서、내몽고;제V류주요분포우저하、감숙、청해;제Ⅵ류주요분포우협서、사천、중경、운남、귀주、신강、서장.결론 취류결과명학료중국직장항문폐쇄/협착적공간분포특정급기규률,대우진일보분석직장항문폐쇄/협착적배경영향인소화구역화감측구유중요적지도의의.
Objective To investigate the geographic distribution panem of patients with anorectal atresia/stenosis in China.in order to provide clue for research on its etiology.Methods Data were collected from Chinese Birth Defects Monitoring Network(CBDMN),which was a hospital-based congenital malformations registry system.From 2001 to 2005,all fetuses with more than 28 weeks of gestation and neonates up to 7 days of age,were monitored.Two-dimensional graphic cluster method was used to divide monitoring stations into difierent classes with the incidence rates of anorectal atresia/stenosis.Results The overall incidence of anorectal atresia/stenosis was 3.17 per 10000 during 2001 to 2005.The incidence was higher in Eastern than that in Mid or Western paas of China and tbe difierence was statistically significant(z=2.50,3.69;P=0.012,＜0.001).The monitoring stations were grouped into 6 classes.Class I was with Helongjiang,Jilin and Liaoling;Class Ⅱ was with Fujian,Guangdong,Hainan,Guangxi,and South Hunan and Jiangxi;ClassⅢwas with Beijing,Tianjin,Hebei,Shandong,and Noah Jiangsu and Anhui;Class Ⅳ was with Zhejiang,Shanghai,South Anhui and Jiangsu,Noah Hunan and Jiangxi,Hubei,Henan,Shanxi and Inner Mongolia,Class V was with Ningxia,Gansu and Qinghai;and Class Ⅳ was with Shaanxi,Sichuan,Chongqing,Yunnan,Guizhou.Xinjiang and Tibet.Conclusion Our findings discovered the geographic distribution patterns of patients with anorectal atresia/stenosis in China.It is important to further analyze the relevant environmental factors attached to it so a beRer regional monitoring system for anorectal atresia/stenosis can be operated.