CAJ | 학술논문

目的探讨人工寒潮对颈动脉粥样硬化性大鼠血压的影响以及尼莫地平的干预作用.方法将SD大鼠按随机数字表法分为正常组、假手术组和颈动脉粥样硬化组,其中颈动脉粥样硬化组再分为非寒潮组、寒潮组和干预组3个亚组,除非寒潮组外其他各组均经历人工寒潮3d,寒潮组并给予等剂量生理盐水灌胃3 d,干预组并给予尼莫地平干预,分别测量各组经历寒潮前后的血压.结果 (1)寒潮前假手术组及颈动脉粥样硬化组血压明显高于正常组,比较差异有统计学意义(P＜0.05).(2)寒潮后正常组、假手术组及寒潮组的血压较寒潮前明显增高,干预组血压较寒潮前明显下降,比较差异均有统计学意义(P＜0.05).(3)正常组、假手术组及寒潮组之间寒潮前后血压的差值比较无统计学差异.(4)与寒潮组相比,干预组的血压差值明显降低,比较差异有统计学意义(P＜0.05).结论人工寒潮可以使正常大鼠及颈动脉粥样硬化性大鼠血压升高,尼莫地平可以预防寒潮导致的血压升高.
목적 탐토인공한조대경동맥죽양경화성대서혈압적영향이급니막지평적간예작용.방법 장SD대서안수궤수자표법분위정상조、가수술조화경동맥죽양경화조,기중경동맥죽양경화조재분위비한조조、한조조화간예조3개아조,제비한조조외기타각조균경력인공한조3d,한조조병급여등제량생리염수관위3 d,간예조병급여니막지평간예,분별측량각조경력한조전후적혈압.결과 (1)한조전가수술조급경동맥죽양경화조혈압명현고우정상조,비교차이유통계학의의(P＜0.05).(2)한조후정상조、가수술조급한조조적혈압교한조전명현증고,간예조혈압교한조전명현하강,비교차이균유통계학의의(P＜0.05).(3)정상조、가수술조급한조조지간한조전후혈압적차치비교무통계학차이.(4)여한조조상비,간예조적혈압차치명현강저,비교차이유통계학의의(P＜0.05).결론 인공한조가이사정상대서급경동맥죽양경화성대서혈압승고,니막지평가이예방한조도치적혈압승고.
Objective To study the effect of artificial cold exposure (ACE) on the level of blood pressure in carotid atherosclerotic rats, and the prophylactic effect of nimodipine on it. Methods One hundred and thirty SD rats were randomly divided into normal group (n=10), sham-operated group (n=10), and carotid atherosclerotic (CAS) group (n=110). High-fat diet was given to the sham-operated group and CAS group; normal diet was given to the control group. Then, 105 alive rats in the CAS group were further sub-divided into non-ACE group (n=40), ACE group (n=38) and nimodipine treatment group (n=37). All the groups were subjected to ACE for 3 d except non-ACE group, and kept at 22 °C throughout the experiment. During the ACE, an intragastric administration of nimodipine was given to the nimodipine treatment group. The changes of the blood pressure before and after ACE were analyzed and compared. Results The level of pre-ACE blood pressure in the sham-operated group and CAS group was significantly higher than that in the normal group (P＜0.05). The level of post-ACE blood pressure was significantly increased in the normal group, sham-operated group and ACE group, and significantly decreased in the nimodipine treatment group as compared with the level of pre-ACE one in these groups (P＜0.05). No significant differences were noted between the levels of pre-ACE and post-ACE blood pressure in the normal group, sham-operated group and ACE group (P＞0.05). The level of post-ACE blood pressure in rats treated with nimodipine was obviously decreased as compared with that in the ACE group (P＜0.05). Conclusion ACE could increase the level of blood pressure in carotid atherosclerotic rats and this effect might be lessoned by the administration of nimodipine.