华中科技大学学报(医学英德文版)
華中科技大學學報(醫學英德文版)
화중과기대학학보(의학영덕문판)
JOURNAL OF TONGJI MEDICAL UNIVERSITY
2002年
3期
180-182
,共3页
ethidium bromide%mytomycin C%2-amino fluorine%dark variant%reversion mutation%gene toxicant monitoring
Summary: The luminous intensity of dark variant (S1) separated from photobacterium phosphoreum (A2) was 1/10 000 less than that of wild-type. Ethidium bromide (EB) (0.6 mg/L), Mytomycin C (MC, 0. 05 mg/L), 2-amino fluorene (2-AF, 1.0 mg/L) all could strongly induce reversion mutation for S1 within 24 h and increase reversion ratio significantly. The results of experiments indicated that these revertants had stable genetic characteristic and the mutation may take place at gene levels. The mutagenesis to S1 caused by EB, MC and 2-AF was detected and it may be used as a new rapid, simple and sensitive method for gene toxicant monitoring.
