中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2008年
8期
1327-1328
,共2页
肾衰竭%慢性%C-反应蛋白%纤维蛋白原%他汀类药物
腎衰竭%慢性%C-反應蛋白%纖維蛋白原%他汀類藥物
신쇠갈%만성%C-반응단백%섬유단백원%타정류약물
Chronic renal failure%C-reactive protein%Fibrnogen%Ststins
目的 观察慢性肾功能衰竭(CRF)患者C-反应蛋白(CRP)、纤维蛋白原(Fg)的变化,探讨他汀类药物对CRF患者炎性反应的影响.方法 将54例CRF患者随机平均分为两组:非他汀组予常规治疗;他汀组予常规治疗加普伐他汀20 mg/d或辛伐他汀20 mg/d.同时设健康对照组20例.测定各组治疗前和治疗4周后CRP、Fg水平.结果 CRF患者治疗前CRP、Fg显著高于对照组,差异有统计学意义(P＜0.05).治疗4周后,他汀组CRP、Fg水平下降,与治疗前及同期非他汀组相比,差异有统计学意义(P＜0.05).结论 (1)CRF患者中存在CRP水平升高的炎性反应;(2)他汀类药物可以降低CRP、Fg水平,提示其具有降脂以外的抗炎作用.
目的 觀察慢性腎功能衰竭(CRF)患者C-反應蛋白(CRP)、纖維蛋白原(Fg)的變化,探討他汀類藥物對CRF患者炎性反應的影響.方法 將54例CRF患者隨機平均分為兩組:非他汀組予常規治療;他汀組予常規治療加普伐他汀20 mg/d或辛伐他汀20 mg/d.同時設健康對照組20例.測定各組治療前和治療4週後CRP、Fg水平.結果 CRF患者治療前CRP、Fg顯著高于對照組,差異有統計學意義(P＜0.05).治療4週後,他汀組CRP、Fg水平下降,與治療前及同期非他汀組相比,差異有統計學意義(P＜0.05).結論 (1)CRF患者中存在CRP水平升高的炎性反應;(2)他汀類藥物可以降低CRP、Fg水平,提示其具有降脂以外的抗炎作用.
목적 관찰만성신공능쇠갈(CRF)환자C-반응단백(CRP)、섬유단백원(Fg)적변화,탐토타정류약물대CRF환자염성반응적영향.방법 장54례CRF환자수궤평균분위량조:비타정조여상규치료;타정조여상규치료가보벌타정20 mg/d혹신벌타정20 mg/d.동시설건강대조조20례.측정각조치료전화치료4주후CRP、Fg수평.결과 CRF환자치료전CRP、Fg현저고우대조조,차이유통계학의의(P＜0.05).치료4주후,타정조CRP、Fg수평하강,여치료전급동기비타정조상비,차이유통계학의의(P＜0.05).결론 (1)CRF환자중존재CRP수평승고적염성반응;(2)타정류약물가이강저CRP、Fg수평,제시기구유강지이외적항염작용.
Objective To observe the changes of serum CRP and plasma Fg in patients with chronic renal failure(CRF),to explore the effect of statins on inflammaory reaction in CRF patients.Methods 54 patients with CRF were randomly divided into non-statins group(routine therapy);atstina group(routine therapy plus simvastatin 20mg/d or pravastatin 20mg/d).Besides,a healthy control group consisted of 20 subjects was set up as control group.The changes of serum of CRP and plasma Fg of all groups before and four weeks after treatment were recorded.Results The serum CRP and plasma Fg levels increased in CRF patients,Which were significantly higher as compared to the control group.After treatment for four weeks,the level of CRP,Fg of matins group decreased significantly.The levels of CRP,Fg had no statistical changes in non-statins group.As compared to non-statins group,the differences of CRP,Fg levels after treatment in statins group were statistically significant respectively.Conclusions(1)Inilammaory reaction is a common condition in non-dialysis patients with CRF;(2)ststins show effects on decrease of CRP,Fg level in CRF patients,independently on the effect of decreasing hypedipemia.
