中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2008年
3期
176-179
,共4页
张登科%郝伟%石富娟%苏巧荣%张宏卫%谌红献
張登科%郝偉%石富娟%囌巧榮%張宏衛%諶紅獻
장등과%학위%석부연%소교영%장굉위%심홍헌
受体,多巴胺D2%多巴胺激动剂%特麦角脲%海洛因依赖%自身给药
受體,多巴胺D2%多巴胺激動劑%特麥角脲%海洛因依賴%自身給藥
수체,다파알D2%다파알격동제%특맥각뇨%해락인의뢰%자신급약
Receptors,dopamine D2%Dopamine agonists%Terguride%Heroin dependence%Self administration
目的 观察多巴胺D2受体部分激动剂--特麦角脲对大鼠海洛因固定比率、累进比率自身给药行为的影响.方法 对64只雄性SD大鼠分别处理如下:(1)取16只大鼠训练自身给水(自然奖赏模型对照),造模成功后随机分为2组,分别接受特麦角脲0.4 mg/kg和生理盐水腹腔注射干预,观察对大鼠固定比率自身给水行为的影响.(2)取32只大鼠训练海洛因固定比率自身给药,自身给药行为稳定后随机分为4组,每组8只,分别腹腔注射特麦角脲3种剂量(0.1,0.2,0.4 mg/kg体质量)和生理盐水(对照组),观察不同剂量特麦角脲对大鼠海洛因固定比率自身给药行为的影响.(3)取16只大鼠训练海洛因累进比率自身给药,造模成功后随机分为2组,分别接受特麦角脲0.4mg/kg和生理盐水腹腔注射干预,观察对大鼠海洛因累进比率自身给药行为的影响.结果 (1)特麦角脲0.4 mg/kg组固定比率自身给水行为与生理盐水干预组相比,差异无统计学意义(P>0.05).(2)特麦角脲0.2 mg/kg组和0.4 mg/kg组的大鼠海洛因固定比率自身给药次数干预前后的差值[(6.25±3.31)次和(11.75±4.92)次]高于生理盐水对照组[(-1.12±4.30)次],差异均有统计学意义(均P<0.01).(3)特麦角脲0.4 mg/kg组的大鼠累进比率自身给药的断点干预前后的差值[(20.2±8.7)次]高于生理盐水组[(-1.1±4.3)次],差异有统计学意义(P<0.01).结论 D2受体部分激动剂特麦角脲可降低海洛因固定比率和累进比率自身给药行为,以降低海洛因使用期的强化效应.
目的 觀察多巴胺D2受體部分激動劑--特麥角脲對大鼠海洛因固定比率、纍進比率自身給藥行為的影響.方法 對64隻雄性SD大鼠分彆處理如下:(1)取16隻大鼠訓練自身給水(自然獎賞模型對照),造模成功後隨機分為2組,分彆接受特麥角脲0.4 mg/kg和生理鹽水腹腔註射榦預,觀察對大鼠固定比率自身給水行為的影響.(2)取32隻大鼠訓練海洛因固定比率自身給藥,自身給藥行為穩定後隨機分為4組,每組8隻,分彆腹腔註射特麥角脲3種劑量(0.1,0.2,0.4 mg/kg體質量)和生理鹽水(對照組),觀察不同劑量特麥角脲對大鼠海洛因固定比率自身給藥行為的影響.(3)取16隻大鼠訓練海洛因纍進比率自身給藥,造模成功後隨機分為2組,分彆接受特麥角脲0.4mg/kg和生理鹽水腹腔註射榦預,觀察對大鼠海洛因纍進比率自身給藥行為的影響.結果 (1)特麥角脲0.4 mg/kg組固定比率自身給水行為與生理鹽水榦預組相比,差異無統計學意義(P>0.05).(2)特麥角脲0.2 mg/kg組和0.4 mg/kg組的大鼠海洛因固定比率自身給藥次數榦預前後的差值[(6.25±3.31)次和(11.75±4.92)次]高于生理鹽水對照組[(-1.12±4.30)次],差異均有統計學意義(均P<0.01).(3)特麥角脲0.4 mg/kg組的大鼠纍進比率自身給藥的斷點榦預前後的差值[(20.2±8.7)次]高于生理鹽水組[(-1.1±4.3)次],差異有統計學意義(P<0.01).結論 D2受體部分激動劑特麥角脲可降低海洛因固定比率和纍進比率自身給藥行為,以降低海洛因使用期的彊化效應.
목적 관찰다파알D2수체부분격동제--특맥각뇨대대서해락인고정비솔、루진비솔자신급약행위적영향.방법 대64지웅성SD대서분별처리여하:(1)취16지대서훈련자신급수(자연장상모형대조),조모성공후수궤분위2조,분별접수특맥각뇨0.4 mg/kg화생리염수복강주사간예,관찰대대서고정비솔자신급수행위적영향.(2)취32지대서훈련해락인고정비솔자신급약,자신급약행위은정후수궤분위4조,매조8지,분별복강주사특맥각뇨3충제량(0.1,0.2,0.4 mg/kg체질량)화생리염수(대조조),관찰불동제량특맥각뇨대대서해락인고정비솔자신급약행위적영향.(3)취16지대서훈련해락인루진비솔자신급약,조모성공후수궤분위2조,분별접수특맥각뇨0.4mg/kg화생리염수복강주사간예,관찰대대서해락인루진비솔자신급약행위적영향.결과 (1)특맥각뇨0.4 mg/kg조고정비솔자신급수행위여생리염수간예조상비,차이무통계학의의(P>0.05).(2)특맥각뇨0.2 mg/kg조화0.4 mg/kg조적대서해락인고정비솔자신급약차수간예전후적차치[(6.25±3.31)차화(11.75±4.92)차]고우생리염수대조조[(-1.12±4.30)차],차이균유통계학의의(균P<0.01).(3)특맥각뇨0.4 mg/kg조적대서루진비솔자신급약적단점간예전후적차치[(20.2±8.7)차]고우생리염수조[(-1.1±4.3)차],차이유통계학의의(P<0.01).결론 D2수체부분격동제특맥각뇨가강저해락인고정비솔화루진비솔자신급약행위,이강저해락인사용기적강화효응.
Objective To characterize the effects of terguride, a partial dopamine agonist at the D2 receptor subtype, on intravenous self-administration of heroin in fixed ratio and progressive ratio schedule. Methods The male adult Sprague-Dawley rats were trained to serf administrate heroin under fixed ratio and progressive ratio, water self administration was set as natural reward control group. The effects of acute administration of terguride (0.1-0.4 mg/kg i. p. ) or saline were compared. Results Compared with saline group, terguride significantly and dose-dependently reduced the responding of heroin self administration under fixed ratio. In addition, terguride at the dose of 0.4 mg/kg significantly decreased the maximum number of responses delivered for a single injection of heroin (" breaking point") under progressive ratio. Terguride had no significant effect on water self administration under fixed ratio. Conclusion The D2 partial agonist terguride could reduce the reinforcing property of heroin.
