中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2011年
6期
462-466
,共5页
欧丹%张云燕%何霞云%顾雅佳%胡超苏%应红梅%朱国培%吴永如%毛健%沈茜刚%岳磊
歐丹%張雲燕%何霞雲%顧雅佳%鬍超囌%應紅梅%硃國培%吳永如%毛健%瀋茜剛%嶽磊
구단%장운연%하하운%고아가%호초소%응홍매%주국배%오영여%모건%침천강%악뢰
磁共振涎管成像%放射性口腔干燥%鼻咽肿瘤/放射疗法
磁共振涎管成像%放射性口腔榦燥%鼻嚥腫瘤/放射療法
자공진연관성상%방사성구강간조%비인종류/방사요법
Magnetic resonance sialography%Radiation-induced xerostomia%Nasopharyngeal neoplasms/radiotherapy
目的 探索磁共振涎管成像(MRS)评价鼻咽癌放疗前后涎腺影像变化的可行性,及其与患者主观评价的相关性.方法 放疗前、后患者分别行MRS,应用MRS评分系统对患者放疗前、后酸刺激前后涎腺导管进行评分,并结合美国放疗肿瘤组织急性放射损伤标准和欧洲癌症研究与治疗组织QLQ-C30v3.0和QLQ-H&N35量表进行分析.结果 共10例患者进入研究.所有患者双侧腮腺平均受照剂量为(37.99 ±3.70) Gy,双侧颌下腺平均受照剂量为(55.65±2.99) Gy.MRS图像显示酸刺激使涎腺导管评分升高,放疗后导管评分下降,对酸刺激反应较放疗前差.放疗后酸刺激前后腮腺导管评分差值与QLQ-C30量表的总生活质量领域得分呈正相关性(rs=0.636,P=0.048),与QLQ-H&N35量表中的口干条目得分呈负相关性(rs=-0.694,P=0.026).结论 MRS可无创检测涎腺放疗前后影像变化,用来评价鼻咽癌患者放疗后早期口干严重程度有一定的临床参考价值.
目的 探索磁共振涎管成像(MRS)評價鼻嚥癌放療前後涎腺影像變化的可行性,及其與患者主觀評價的相關性.方法 放療前、後患者分彆行MRS,應用MRS評分繫統對患者放療前、後痠刺激前後涎腺導管進行評分,併結閤美國放療腫瘤組織急性放射損傷標準和歐洲癌癥研究與治療組織QLQ-C30v3.0和QLQ-H&N35量錶進行分析.結果 共10例患者進入研究.所有患者雙側腮腺平均受照劑量為(37.99 ±3.70) Gy,雙側頜下腺平均受照劑量為(55.65±2.99) Gy.MRS圖像顯示痠刺激使涎腺導管評分升高,放療後導管評分下降,對痠刺激反應較放療前差.放療後痠刺激前後腮腺導管評分差值與QLQ-C30量錶的總生活質量領域得分呈正相關性(rs=0.636,P=0.048),與QLQ-H&N35量錶中的口榦條目得分呈負相關性(rs=-0.694,P=0.026).結論 MRS可無創檢測涎腺放療前後影像變化,用來評價鼻嚥癌患者放療後早期口榦嚴重程度有一定的臨床參攷價值.
목적 탐색자공진연관성상(MRS)평개비인암방료전후연선영상변화적가행성,급기여환자주관평개적상관성.방법 방료전、후환자분별행MRS,응용MRS평분계통대환자방료전、후산자격전후연선도관진행평분,병결합미국방료종류조직급성방사손상표준화구주암증연구여치료조직QLQ-C30v3.0화QLQ-H&N35량표진행분석.결과 공10례환자진입연구.소유환자쌍측시선평균수조제량위(37.99 ±3.70) Gy,쌍측합하선평균수조제량위(55.65±2.99) Gy.MRS도상현시산자격사연선도관평분승고,방료후도관평분하강,대산자격반응교방료전차.방료후산자격전후시선도관평분차치여QLQ-C30량표적총생활질량영역득분정정상관성(rs=0.636,P=0.048),여QLQ-H&N35량표중적구간조목득분정부상관성(rs=-0.694,P=0.026).결론 MRS가무창검측연선방료전후영상변화,용래평개비인암환자방료후조기구간엄중정도유일정적림상삼고개치.
Objective To investigate the value of magnetic resonance sialography (MRS) as a noninvasive tool in evaluating major salivary gland function before and after radiotherapy (RT) for nasopharyngeal carcinoma patients.Methods From August 2009 to June 2010,patients with stage Ⅰ and Ⅱa (AJCC/UICC 2002) nasopharyngeal carcinoma were enrolled.All the patients were treated with intensity modulated radiation therapy alone.MRS with salivary stimulation was performed in patients before and after RT on a 3.0T MR scanner.An MRS categorical scoring system was used to compare the visibility of ducts pre-RT and post-RT.The relationship between MRS score and EORTC Core QOL and EORTC Head and Neck QOL was analyzed.Spearman rank correlation test was performed to analyze the non-stimulated and stimulated MRS findings and the clinical severity of xerostomia.Results All 10 enrolled patients completed planned treatment.The mean dose of the parotid glands and submandibular glands were (37.99 + 3.70) Gy and (55.65 + 2.99) Gy,respectively.Good-quality MRS images were obtained.The visibility scores of both the parotid and submandibular ducts were increased after secretion stimulation.Irradiation decreased the visualization of the salivary ducts and attenuated the response to secretion stimulation.There were specific correlations between post-RT secretion response of the parotid gland and EORTC QLQ scales ( global QOL scale in QLQ-C30 ( rs =0.636,P =0.048 ) and xerostomia scale in QLQ H&N35 ( rs =- 0.694,P =0.026) ).Conclusions MRS can be used as a non-invasive way to evaluated of the functional changes of major salivary glands before and after RT and as a promising approach for investigating radiation-induced xerostomia.
