CAJ | 학술논문

目的探讨系统性红斑狼疮(SLE)与人类白细胞抗原(HLA)-Cw等位基因的相关性.方法应用聚合酶链反应-序列特异性引物(PCR-SSP)的方法对108例SLE患者和102名健康人HLA-Cw01-08等位基因进行检测,比较两组间各等位基因的基因表型频率分布差异.结果 SLE患者组中HLA-Cw07的基因表型频率高于对照组,差异有统计学意义.结论 HLA-Cw07可能是SLE的易感基因或易感连锁基因.
목적 탐토계통성홍반랑창(SLE)여인류백세포항원(HLA)-Cw등위기인적상관성.방법 응용취합매련반응-서렬특이성인물(PCR-SSP)적방법대108례SLE환자화102명건강인HLA-Cw01-08등위기인진행검측,비교량조간각등위기인적기인표형빈솔분포차이.결과 SLE환자조중HLA-Cw07적기인표형빈솔고우대조조,차이유통계학의의.결론 HLA-Cw07가능시SLE적역감기인혹역감련쇄기인.
Objective To explore the association between HLA-Cw alleles with systemic lupuserythematosus. Methods Polymerase chain reaction-sequence specific primer method was used to analyze thedistribution of HLA-Cw01-08 alleles among 108 patients with SLE and 102 healthy controls. The allelefrequencies was compared between various patient groups and the control population. Results The frequencyof HLA-Cw07 alleles in patients with SLE was significantly increased in patients with SLE. Conclusion Theresults indicate that HLA-Cw07 may be the susceptible alleles or may be closely linked to the susceptiblegenes for SLE.