CAJ | 학술논문

目的探讨纳米铁微粒作为显影标记物对医用硅橡胶改性的可行性并评价复合材料的影像可视性.方法硅油与纯铁粉、碳包铁粉混合,按预定的配方比分别与甲基乙烯基硅橡胶共混、密炼、模压、硫化,得到纳米纯铁粉增强硅橡胶(第1组)、纳米碳包铁粉增强硅橡胶(第2组),空白对照组为医用硅橡胶.CT扫描体外各组材料试件,获取图像并测得CT值,比较组间CT值均值的差异性;将2组材料试件植入犬皮下,获得标准X-线图像;X射线衍射技术分析材料内铁微粒的组分稳定性.结果分别制备出铁粉显影增强硅橡胶和碳包铁粉显影增强硅橡胶,新材料在体内外的X-线图像清晰可见,复合材料的CT值随金属纳米粉体量和纳米微粒原子量的增加而增加,2组材料的CT值均值、组间配方比相同的材料的CT值均值差异显著(P＜0.001);材料放置180 d后,单质铁出现衍射峰的位置基本没有变化,分散在硅橡胶中的纳米纯铁微粒、碳包铁微粒较为稳定.结论金属纳米铁粉、碳包铁粉可作为硅橡胶显影性改良的标记物.
목적 탐토납미철미립작위현영표기물대의용규상효개성적가행성병평개복합재료적영상가시성.방법 규유여순철분、탄포철분혼합,안예정적배방비분별여갑기을희기규상효공혼、밀련、모압、류화,득도납미순철분증강규상효(제1조)、납미탄포철분증강규상효(제2조),공백대조조위의용규상효.CT소묘체외각조재료시건,획취도상병측득CT치,비교조간CT치균치적차이성;장2조재료시건식입견피하,획득표준X-선도상;X사선연사기술분석재료내철미립적조분은정성.결과 분별제비출철분현영증강규상효화탄포철분현영증강규상효,신재료재체내외적X-선도상청석가견,복합재료적CT치수금속납미분체량화납미미립원자량적증가이증가,2조재료적CT치균치、조간배방비상동적재료적CT치균치차이현저(P＜0.001);재료방치180 d후,단질철출현연사봉적위치기본몰유변화,분산재규상효중적납미순철미립、탄포철미립교위은정.결론 금속납미철분、탄포철분가작위규상효현영성개량적표기물.
Objective To explore the feasibility of iron nanoparticles as radiopaque agents for modifying medical silicone rubber and to evaluate image visibility of modified materials.Methods Methyl vinyl silicone elastomer was mixed with iron nanoparticles,carbon-coated ferric nanoparticles,respectively,in accordance with the designed formula ratios.The composites were blended,mixed,molded and vulcanized with.Two groups of new materials,iron nanoparticle enhanced silicone rubber (INESR,Group1) and carbon-coated ferric nanoparticle enhanced silicone rubber(Fe/CESR,Group2),were harvested.Medical silicone rubber was as a negative control group.CT scanning of each group of material samples in vitro was performed,and both CT images and measured CT values were collected.Differences in CT mean values between the groups were compared.Samples of new material groups were implanted subcutaneously in a dog and standardized radiographic images were obtained.X-Ray Diffraction was used to analyze the component stability of iron nanoparticles dispersing in the silicone rubber.Results Two groups of radiographic image enhanced silicone rubber were prepared.The X-ray images of new composites were clearly visible both in vitro and in vivo.CT values were increased with the increase of added metal nanoparticles and metal atomic weight.CT mean values of each group and the materials in Group 1 and Group2 with the same material formulation were significantly different (P＜0.001).After placed for 180 days,the diffraction peak positions of elemental iron in both groups of materials remained essentially unchanged,and it showed that dispersed iron nanoparticles and carbon-coated iron nanopaarticles in silicone rubber were stable.Conclusion The metal nanoparticles of iron and carbon-coated ferrum can be used as radiographic markers for improving quality of X-Ray image of the medical silicone rubber.