CAJ | 학술논문

转化生长因子-β(TGF-β)是一类具有多种生物学效应的细胞因子.正常情况下,TGF-β以无活性的潜伏态形式合成分泌,且必须在某种机制下活化才能发挥其生物学作用.近年来研究发现,TGF-β在体内主要以两种途径活化:蛋白水解途径及非蛋白水解途径,需要多种细胞内蛋白参与,其中血小板反应素-1(TSP-1)和av族整合素的作用尤其重要.因而进一步了解TGF-β的活化机制有利于从分子水平上开辟新的研究方向及TGF-β的生物学应用.
전화생장인자-β(TGF-β)시일류구유다충생물학효응적세포인자.정상정황하,TGF-β이무활성적잠복태형식합성분비,차필수재모충궤제하활화재능발휘기생물학작용.근년래연구발현,TGF-β재체내주요이량충도경활화:단백수해도경급비단백수해도경,수요다충세포내단백삼여,기중혈소판반응소-1(TSP-1)화av족정합소적작용우기중요.인이진일보료해TGF-β적활화궤제유리우종분자수평상개벽신적연구방향급TGF-β적생물학응용.
Transforming growth factor-β(TGF-β)is a kind of muhipotent cytokines.Normarly,TGF-β is secreted as inactive form.To exert its biological functions,it needs to be activated under certain mecha-nisms.Reserches have shown that TGF-β is mainly activated through two pathways in vivo:proteolysis and non-pmteolysis.Many intraeellular proteins are involved in the activation of TGF-β.TSP-1 and av integrins are especially important.Further understanding the mechanisms of TGF-β activation may be beneficial to the finding of new research fields and the application of TGF-β.