CAJ | 학술논문

目的研究亚临床甲状腺功能减退(亚临床甲减)对冠状动脉粥样硬化性心脏病(冠心病)患者C反应蛋白(CRP)及尿微量白蛋白(MAU)的影响.方法选取冠心病合并亚临床甲减及冠心病无亚临床甲减患者各40例,所有患者均检测血甘油三酯、总胆固醇、同型半胱氨酸(Hcy)、CRP及MAU水平,并比较2组的差异.结果与冠心病无亚临床甲减患者相比,冠心病合并亚临床甲减患者甘油三酯、总胆固醇、CRP、MAU均升高[(1.7±0.8)mmol/L比(1.5±0.5)mmol/L,(5.7±0.8)mmol/L比(4.5±0.7)mmol/L,(4.8±1.6)mg/L比(3.1±1.3)mg/L,(51.2±3.5)mg/L比(42.4±4.7)mg/L],差异均有统计学意义(P＜0.05或P＜0.01).结论亚临床甲减不但影响冠心病患者血脂代谢,而且会增加冠心病患者CRP及MAU水平,从而可能增加冠心病患者心血管风险.
목적 연구아림상갑상선공능감퇴(아림상갑감)대관상동맥죽양경화성심장병(관심병)환자C반응단백(CRP)급뇨미량백단백(MAU)적영향.방법 선취관심병합병아림상갑감급관심병무아림상갑감환자각40례,소유환자균검측혈감유삼지、총담고순、동형반광안산(Hcy)、CRP급MAU수평,병비교2조적차이.결과 여관심병무아림상갑감환자상비,관심병합병아림상갑감환자감유삼지、총담고순、CRP、MAU균승고[(1.7±0.8)mmol/L비(1.5±0.5)mmol/L,(5.7±0.8)mmol/L비(4.5±0.7)mmol/L,(4.8±1.6)mg/L비(3.1±1.3)mg/L,(51.2±3.5)mg/L비(42.4±4.7)mg/L],차이균유통계학의의(P＜0.05혹P＜0.01).결론 아림상갑감불단영향관심병환자혈지대사,이차회증가관심병환자CRP급MAU수평,종이가능증가관심병환자심혈관풍험.
Objective To observe the influence of subclinical hypothyroidism on c-reactive protein (CRP) and microalbuminuria (MAU) in patients with coronary heart disease. Methods The level of serum triglyceride ( TG), total cholesterol( TC), homocysteine (Hcy), CRP and urinary MAU was measured in 80 patients with coronary heart disease (of them 40 complicated with subclinical hypothyroidism). Results The levels of TG, TC,CRP, and MAU increased significantly in the patients complicated with subclinical hypothyroidism as compared with those without subclinical hypothyroidism ([(1.7±0.8)mmol/L vs (1.5±0.5)mmol/L, ( 5.7 ± 0.8 ) mmol/L vs (4.5 ±0.7)mol/L, (4.8 ± 1.6)mg/L vs (3.1 ± 1.3)mg/L, (51.2 ±3.5)mg/L vs (42.4±4.7)mg/L]P＜0.01 or P＜0.05). Conclusions Subclinical hypothyroidism can not only affect lipid metabolism, but also increase inflammation and microalbuminuria in patients with coronary heart disease.