CAJ | 학술논문

Wnt/β-catenin通路在结直肠癌的发生发展过程中起重要作用,其致癌的关键是β-catenin蛋白降解障碍使其在胞内积聚及核易位,并激活下游肿瘤相关性靶基因的转录,不稳定编码区结合蛋白(CRD-BP)是其靶基因之一.在正常细胞中β-catenin降解依赖于β-转导重复相容蛋白(β-Trcp),而在异常细胞中CRD-BP的表达可调控β-Trcp的稳定性.Wnt/β-catenin通路的激活、β-catenin及CRD-BP的高表达、CRD-BP上调β-Trcp与结直肠癌发生、发展及侵袭转移密切相关.
Wnt/β-catenin통로재결직장암적발생발전과정중기중요작용,기치암적관건시β-catenin단백강해장애사기재포내적취급핵역위,병격활하유종류상관성파기인적전록,불은정편마구결합단백(CRD-BP)시기파기인지일.재정상세포중β-catenin강해의뢰우β-전도중복상용단백(β-Trcp),이재이상세포중CRD-BP적표체가조공β-Trcp적은정성.Wnt/β-catenin통로적격활、β-catenin급CRD-BP적고표체、CRD-BP상조β-Trcp여결직장암발생、발전급침습전이밀절상관.
Wnt/β-catenin signaling pathway plays an important role in the initiation and progression of colorectal cancer. The key to its carcinogenicity is related to the inhibition of β-catenin degradation, and the subsequent cytoplasmic accumulation and nuclear translocation of β-catenin, which activates the transcription of downstream target genes such as coding region instability determinant-binding protein (CRD-BP). In cancercells ,the expression of CRD-BP mediates the stabilization of β-Trcp, which in normal cells regulates the degradation of β-catenin. The activation of Wnt/β-catenin signaling pathway, overexpression of β-catenin and CRDBP, and the upregulation of β-Trcp by CRD-BP play important roles in the initiation, progression, and metastasis of colorectal cancer.