CAJ | 학술논문

随着分子靶向药物和个体化治疗的研发和临床使用,肿瘤的基因靶向检测和治疗已成为肿瘤治疗的热点.尤其是针对表皮生长因子受体(EGFR)信号通路相关基因、DNA复制相关基因、纺锤体形成相关基因、细胞代谢过程相关基因等分子靶向检测和治疗,靶点分子的基因多态性决定了靶向药物治疗的有效性.
수착분자파향약물화개체화치료적연발화림상사용,종류적기인파향검측화치료이성위종류치료적열점.우기시침대표피생장인자수체(EGFR)신호통로상관기인、DNA복제상관기인、방추체형성상관기인、세포대사과정상관기인등분자파향검측화치료,파점분자적기인다태성결정료파향약물치료적유효성.
With the development and clinical use of the molecular targeted drugs and individualized treatment,cancer research has been focused on gene targeting diagnosis and treatment.Especially for the epidermal growth factor receptor (EGFR) signaling pathway-related genes,DNA replication-related genes,spindle apparatus format-related genes,cell metabolism-related genes and other molecular targeted detection and treatment,the polymorphism of targeting genes/molecules determines the clinical efficiency of the therapies.