CAJ | 학술논문

目的探讨高危型人乳头状瘤病毒(hish-risk human papillomavirus,HR-HPV)和宫颈细胞学联合检测在诊断宫颈病变中的临床价值.方法对2004年10月至2006年12月北京大学第一医院就诊的患者进行HR-HPV检测和宫颈细胞学检查,对一项或两项结果异常者均行阴道镜下宫颈活检,并以宫颈活检结果为金标准,比较HR-HPV检测、宫颈细胞学检查、HR-HPV和宫颈细胞学联合检测对宫颈病变的诊断价值.结果 HR-HPV检测、宫颈细胞学检查及HR-HPV检测联合宫颈细胞学检查对诊断宫颈病变有不同价值.HR-HPV检测筛查CINⅡ、CINⅢ的敏感度、特异度、阳性预测值和阴性预测值分别为94.83%、31.06%、55.22%、87.02%,宫颈细胞学筛查CINⅡ、CINⅢ的敏感度、特异度、阳性预测值和阴性预测值分别为92.10%、31.06%、54.50%、81.43%,HR-HPV和宫颈细胞学联合检测筛查CINⅡ、CINⅢ的敏感度、特异度、阳性预测值和阴性预测值分别为99.65%、18.55%、61.46%、97.62%.结论采用HR-HPV和宫颈细胞学联合检测可提高宫颈病变的检出率,并可指导临床医生对宫颈病变的治疗.
목적 탐토고위형인유두상류병독(hish-risk human papillomavirus,HR-HPV)화궁경세포학연합검측재진단궁경병변중적림상개치.방법 대2004년10월지2006년12월북경대학제일의원취진적환자진행HR-HPV검측화궁경세포학검사,대일항혹량항결과이상자균행음도경하궁경활검,병이궁경활검결과위금표준,비교HR-HPV검측、궁경세포학검사、HR-HPV화궁경세포학연합검측대궁경병변적진단개치.결과 HR-HPV검측、궁경세포학검사급HR-HPV검측연합궁경세포학검사대진단궁경병변유불동개치.HR-HPV검측사사CINⅡ、CINⅢ적민감도、특이도、양성예측치화음성예측치분별위94.83%、31.06%、55.22%、87.02%,궁경세포학사사CINⅡ、CINⅢ적민감도、특이도、양성예측치화음성예측치분별위92.10%、31.06%、54.50%、81.43%,HR-HPV화궁경세포학연합검측사사CINⅡ、CINⅢ적민감도、특이도、양성예측치화음성예측치분별위99.65%、18.55%、61.46%、97.62%.결론 채용HR-HPV화궁경세포학연합검측가제고궁경병변적검출솔,병가지도림상의생대궁경병변적치료.
Objective To investigate the clinic value of combination of high-risk human papillomavirus test and cervical cytology test in diagnosis of cervical lesions. Methods Patients underwent physical examination at our department were checked by high-risk human papillomavirus test,cervical cytology test and colposcope from October 2004 to December 2006. Abnormal patients with cervical abnormalities were asked for pathological test. The diagnostic value of cervical lesions among these different methods were compared. Results Based on the criteria of histopathology,the sensitivity,specificity,positive-predictive value and negative-predictive value of high-risk human papillomavirus test for detecting all cases of CIN Ⅱ and CIN Ⅲ were 94.83% ,31.06% ,55.22% and 87.02% respectively,and those of the cervical cytology were 92.10% ,31.06% ,54.50% and 81.43% respectively.Those values changed to 99.65%,18.55%,61.46% and 97.62% respectively if two methods were combined. Conclusions Human papillomavims test and cervical cytology test combined with pathological test can improve the detective rate of cervical lesions and facilitate the treatment.