中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2009年
10期
655-658
,共4页
陈莉丽%李强%王薇%崔璨%于萍%鲍莉莉%王君%周健%包玉倩%贾伟平%孙玉倩%张巾超
陳莉麗%李彊%王薇%崔璨%于萍%鮑莉莉%王君%週健%包玉倩%賈偉平%孫玉倩%張巾超
진리려%리강%왕미%최찬%우평%포리리%왕군%주건%포옥천%가위평%손옥천%장건초
糖尿病,2型%一级亲属%动态血糖监测
糖尿病,2型%一級親屬%動態血糖鑑測
당뇨병,2형%일급친속%동태혈당감측
Diabetes mellitus,type 2%First-degree relatives%Continuous glucose monitoring
目的 用持续血糖监测系统(CGMS)评估口服葡萄糖耐量正常人群及2型糖尿病患者一级亲属的血糖稳定性.方法 用CGMS对50例受试者进行48～72 h的血糖监测,其中2型糖尿病患者一级亲属(FDR)22名,尤糖尿病家族史的正常糖调节人群(对照组)28名,比较CGMS监测中连续48 h的平均血糖水平(MBG)及其血糖水平标准差(SDBG)、日内平均血糖波动幅度(MAGE)及日间血糖平均绝对差等指标.用稳态模型评估法评估胰岛β细胞功能和胰岛素抵抗性(HOMA-IR),计算胰岛素分泌指数(△I30/△G30),修正的β细胞功能指数(MBCI)等指标.结果 FDR组的MAGE明显高于对照组[(2.3±0.5)mmol/L比(2.0±0.6)mmol/L,P<0.05)],MBCI在FDR组明显低于对照组[17.6(16.9～50.0)比36.0(15.7～59.6),P<0.05],其余指标在两组间差异无统计学意义.结论 CGMS监测剑2型糖尿病患者的FDR的血糖波动性较大,主要表现为MAGE增大.
目的 用持續血糖鑑測繫統(CGMS)評估口服葡萄糖耐量正常人群及2型糖尿病患者一級親屬的血糖穩定性.方法 用CGMS對50例受試者進行48～72 h的血糖鑑測,其中2型糖尿病患者一級親屬(FDR)22名,尤糖尿病傢族史的正常糖調節人群(對照組)28名,比較CGMS鑑測中連續48 h的平均血糖水平(MBG)及其血糖水平標準差(SDBG)、日內平均血糖波動幅度(MAGE)及日間血糖平均絕對差等指標.用穩態模型評估法評估胰島β細胞功能和胰島素牴抗性(HOMA-IR),計算胰島素分泌指數(△I30/△G30),脩正的β細胞功能指數(MBCI)等指標.結果 FDR組的MAGE明顯高于對照組[(2.3±0.5)mmol/L比(2.0±0.6)mmol/L,P<0.05)],MBCI在FDR組明顯低于對照組[17.6(16.9～50.0)比36.0(15.7～59.6),P<0.05],其餘指標在兩組間差異無統計學意義.結論 CGMS鑑測劍2型糖尿病患者的FDR的血糖波動性較大,主要錶現為MAGE增大.
목적 용지속혈당감측계통(CGMS)평고구복포도당내량정상인군급2형당뇨병환자일급친속적혈당은정성.방법 용CGMS대50례수시자진행48～72 h적혈당감측,기중2형당뇨병환자일급친속(FDR)22명,우당뇨병가족사적정상당조절인군(대조조)28명,비교CGMS감측중련속48 h적평균혈당수평(MBG)급기혈당수평표준차(SDBG)、일내평균혈당파동폭도(MAGE)급일간혈당평균절대차등지표.용은태모형평고법평고이도β세포공능화이도소저항성(HOMA-IR),계산이도소분비지수(△I30/△G30),수정적β세포공능지수(MBCI)등지표.결과 FDR조적MAGE명현고우대조조[(2.3±0.5)mmol/L비(2.0±0.6)mmol/L,P<0.05)],MBCI재FDR조명현저우대조조[17.6(16.9～50.0)비36.0(15.7～59.6),P<0.05],기여지표재량조간차이무통계학의의.결론 CGMS감측검2형당뇨병환자적FDR적혈당파동성교대,주요표현위MAGE증대.
Objective To investigate the characteristics of glycemic stability in the first-degree relatives of type 2 diabetes mellitus (T2DM) patients by continuous glucose monitoring system (CGMS). Methods Twenty-two first-degree relatives (FDRs) of T2DM patients and 28 age and gender-matched controls underwent CGMS to obtain the mean blood glucose (MBG) , standard deviation of MBG (SDBG), mean of daily differences (MODD), and mean amplitude of glycemic excursions (MAGE). Oral glucose tolerance test (OGTT) was conducted. Blood glucose, serum lipids, and serum insulin were assayed. The insulin sensitivity and resistance was assessed by HOMA-β, HOMA-IR, △I30/△G30 and modified β cell function index (MBCI). Results There were no significant differences between the FDR and control groups in the levels of plasma glucose in OGTT, MBG, SDBG, and MOOD. However, the MAGE level of the FDR group was (2.3±0.5) mmol/L, significantly higher than that of the control group [(2.0±0.6) mmol/L, P<0.05]. The MBCI level of the FDR group was 17.6 (16.9-50.0), significantly lower than that of the control group [36.0 (15.7-59.6), P<0.05]. There were no significant differences in the serum lipids profile, body fat distribution, HOMA-β, HOMA-IR, and △I30/△G30 between these two groups. Conclusion The excursion of blood glucose is greater in the FDRs of T2DM patients. CGMS is more sensitive to discover such change than OGTT.
