中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
8期
855-856,859
,共3页
格雷夫斯病%贫血%白细胞减少%血小板减少
格雷伕斯病%貧血%白細胞減少%血小闆減少
격뢰부사병%빈혈%백세포감소%혈소판감소
Graves disease%Anemia%Leukopenia%Thrombocytopenia
目的 探讨Graves病(GD)患者血液学异常的发生率及其相关因素.方法 2007年2月-2009年2月本院内分泌科新诊断GD患者126例,检测患者血清甲状腺激素、甲状腺自身抗体水平及血常规,对其血液学异常的发生率、临床特点及相关因素进行分析.结果 新诊断126例GD患者中,白细胞减少24例(19.0%),其中中性粒细胞减少9例(7.1%);贫血11例(8.7%);血小板减少14例(11.1%);共33例(26.2%)患者发生血液学异常,其中6例白细胞减少合并贫血,7例白细胞减少合并血小板减少.白细胞计数与患者年龄及游离甲状腺原氨酸(FT3)水平呈负相关(P＜0.05);中性粒细胞计数与三碘甲状腺原氨酸(TT3)、FT3、甲状腺素(TT4)、游离甲状腺素(FT4)呈负相关(P＜0.01);血红蛋白及血小板计数仅与患者年龄呈负相关(P＜0.05).结论 GD患者血液学异常的发生率较高,白细胞减少与甲状腺功能亢进症的程度有关;建议行药物治疗之前,需对GD患者行血常规检查,尤其是重症、高龄患者.
目的 探討Graves病(GD)患者血液學異常的髮生率及其相關因素.方法 2007年2月-2009年2月本院內分泌科新診斷GD患者126例,檢測患者血清甲狀腺激素、甲狀腺自身抗體水平及血常規,對其血液學異常的髮生率、臨床特點及相關因素進行分析.結果 新診斷126例GD患者中,白細胞減少24例(19.0%),其中中性粒細胞減少9例(7.1%);貧血11例(8.7%);血小闆減少14例(11.1%);共33例(26.2%)患者髮生血液學異常,其中6例白細胞減少閤併貧血,7例白細胞減少閤併血小闆減少.白細胞計數與患者年齡及遊離甲狀腺原氨痠(FT3)水平呈負相關(P＜0.05);中性粒細胞計數與三碘甲狀腺原氨痠(TT3)、FT3、甲狀腺素(TT4)、遊離甲狀腺素(FT4)呈負相關(P＜0.01);血紅蛋白及血小闆計數僅與患者年齡呈負相關(P＜0.05).結論 GD患者血液學異常的髮生率較高,白細胞減少與甲狀腺功能亢進癥的程度有關;建議行藥物治療之前,需對GD患者行血常規檢查,尤其是重癥、高齡患者.
목적 탐토Graves병(GD)환자혈액학이상적발생솔급기상관인소.방법 2007년2월-2009년2월본원내분비과신진단GD환자126례,검측환자혈청갑상선격소、갑상선자신항체수평급혈상규,대기혈액학이상적발생솔、림상특점급상관인소진행분석.결과 신진단126례GD환자중,백세포감소24례(19.0%),기중중성립세포감소9례(7.1%);빈혈11례(8.7%);혈소판감소14례(11.1%);공33례(26.2%)환자발생혈액학이상,기중6례백세포감소합병빈혈,7례백세포감소합병혈소판감소.백세포계수여환자년령급유리갑상선원안산(FT3)수평정부상관(P＜0.05);중성립세포계수여삼전갑상선원안산(TT3)、FT3、갑상선소(TT4)、유리갑상선소(FT4)정부상관(P＜0.01);혈홍단백급혈소판계수부여환자년령정부상관(P＜0.05).결론 GD환자혈액학이상적발생솔교고,백세포감소여갑상선공능항진증적정도유관;건의행약물치료지전,수대GD환자행혈상규검사,우기시중증、고령환자.
Objective To investigate the prevalence and the possible risk factors of hematological abnormalities in patients with Graves' disease(GD).Methods One hundred twenty-six patients were newly diagnosed as GD in our department of endocrinoliogy from Feb.2007 to Feb.2009.Serum thyroid hormones,thyroid autoantibodies levels and routine blood test were detected to analyze the incidence of abnormal hematology,clinical features and its related factors.Results Among 126 newly diagnosed GD patients,24 presented with leucopenia (19.0%),9 with neutropenia (7.1%),11 with anemia (8.73%),14 with thrombocytopenia (11.1%).There were altogether 33 patients presenting with abnormal hematology (4.76%),including 6 leucopenia complicated by anemia,7 by thrombocytopenia.White blood cell counts were negatively correlated with age,free thyroxin (FT3)level (P＜0.05),neutrophil counts with triiodothyronine (TT3),FT3,thyroxine (TT4),free thyroxine (FT4) (P＜0.01),and hemoglobin and platelet counts with only age (P＜0.05).Conclusion The incidence of hematological abnormalities is relatively high,and leucopenia is related to the degree of hyperthyroidism.It is suggested that blood routine examinations should be conducted in GD patients,especially in severe,elderly patients before drug treatment.
