CAJ | 학술논문

目的:观察采用玻璃化冷冻技术行全胚胎冷冻后解冻移植患者的临床结局,并与同期新鲜周期移植患者相比较,探讨玻璃化冷冻技术在全胚胎冷冻并行复苏移植中的应用价值.方法:全胚胎冷冻组为体外受精(IVF)未移植患者40个周期,新鲜周期组为同期体外受精及胚胎移植(IVF-ET)患者300例,对2组的平均移植胚胎数、优质胚胎数、子宫内膜厚度、雌二醇(E2)水平、临床妊娠率进行比较.结果:2组之间在平均移植胚胎数、优质胚胎数、子宫内膜厚度方面的差异均无统计学意义(P＞0.05);新鲜周期组的E2水平明显高于全胚胎冷冻组(P<0.05), 临床妊娠率明显低于全胚胎冷冻组(P<0.05).结论:玻璃化冷冻技术是一种简便、可靠、高效的胚胎冷冻技术;对于符合要求的患者,全胚胎冷冻并适时行冻胚移植是可行的胚胎移植策略,值得临床深入研究和推广.
목적:관찰채용파리화냉동기술행전배태냉동후해동이식환자적림상결국,병여동기신선주기이식환자상비교,탐토파리화냉동기술재전배태냉동병행복소이식중적응용개치.방법:전배태냉동조위체외수정(IVF)미이식환자40개주기,신선주기조위동기체외수정급배태이식(IVF-ET)환자300례,대2조적평균이식배태수、우질배태수、자궁내막후도、자이순(E2)수평、림상임신솔진행비교.결과:2조지간재평균이식배태수、우질배태수、자궁내막후도방면적차이균무통계학의의(P＞0.05);신선주기조적E2수평명현고우전배태냉동조(P<0.05), 림상임신솔명현저우전배태냉동조(P<0.05).결론:파리화냉동기술시일충간편、가고、고효적배태냉동기술;대우부합요구적환자,전배태냉동병괄시행동배이식시가행적배태이식책략,치득림상심입연구화추엄.
Objective To investigate the clinical outcome of patients who underwent whole embryo vitrification freezing and thawed frozen embryo transplantation, and to compare it with the patients at the same period in the fresh cycle to explore the value of vitrification technology in the whole embryo freezing combined with recovery transplantation. Methods The whole embryo freezing group included 40 untransplanted cases of in-vitro fertilization (IVF), while another 300 patients in the fresh cycle with in vitro fertilization and embryo transfer (IVF-ET) at the same period served as the fresh cycle group. The average number of transferred embryos, high-quality embryos, endometrial thickness, estradiol (E2) level, and clinical pregnancy rate were compared.Results The average number of transferred embryos, high-quality embryos, difference in endometrial thickness were not significant between the 2 groups (P>0.05); the E2 level of the fresh cylcle group was significantly higher than that of the whole embryo freezing group (P<0.05), and the clinical pregnancy rate in the fresh cylcle group was significantly lower than that of the whole embryo freezing group (P<0.05). Conclusion Vitrification technology is a simple, reliable, and efficient embryo freezing technology. For patients who meet the requirements, whole embryo vitrfication freezing and thawed frozen embryo transplantation is feasible. It is worth for further clinical research.