CAJ | 학술논문

目的评价小切口非超声乳化白内障摘除术对角膜内皮的影响.方法临床病例对比研究.收集2010年1月至201 1年6月就诊于福建医科大学附属第一医院眼科的白内障患者123例(136只眼),由同一位医师主刀完成小切口非超声乳化白内障摘除术,术前和术后1周、1月及3月采用角膜内皮镜测量角膜上部、中央区和下部的角膜内皮,计算角膜内皮细胞的密度、丢失率、六边形细胞比例和细胞面积.结果术前角膜上部、中央区和下部的角膜内皮细胞密度、六边形细胞比例和角膜内皮细胞面积差异均无统计学意义(均P ＞0.05).术后角膜内皮细胞密度下降、六边形细胞比例下降、细胞面积扩大.角膜上部、中央区和下部的角膜内皮细胞密度、细胞丢失率、六边形细胞比例和角膜内皮细胞面积差异以1周时差别最大,差异有统计学意义(均P＜0.01)；1月时差异有统计学意义(均P ＜0.05)；3月时差异无统计学意义(均P＞0.05).结论小切口非超声乳化白内障摘除术对角膜内皮细胞损伤小,损伤部位以角膜上部切口处为主.
목적 평개소절구비초성유화백내장적제술대각막내피적영향.방법 림상병례대비연구.수집2010년1월지201 1년6월취진우복건의과대학부속제일의원안과적백내장환자123례(136지안),유동일위의사주도완성소절구비초성유화백내장적제술,술전화술후1주、1월급3월채용각막내피경측량각막상부、중앙구화하부적각막내피,계산각막내피세포적밀도、주실솔、륙변형세포비례화세포면적.결과 술전각막상부、중앙구화하부적각막내피세포밀도、륙변형세포비례화각막내피세포면적차이균무통계학의의(균P ＞0.05).술후각막내피세포밀도하강、륙변형세포비례하강、세포면적확대.각막상부、중앙구화하부적각막내피세포밀도、세포주실솔、륙변형세포비례화각막내피세포면적차이이1주시차별최대,차이유통계학의의(균P＜0.01)；1월시차이유통계학의의(균P ＜0.05)；3월시차이무통계학의의(균P＞0.05).결론 소절구비초성유화백내장적제술대각막내피세포손상소,손상부위이각막상부절구처위주.
Objective To investigate the effect of small incision nonphacoemulsification cataract surgery on corneal endothelial cells. Methods One hundred and twenty-three cataract patients (136eyes) were collected from January 2010 to June 2011 in our hospital.Small incision nonphacoemulsification cataract extraction was performed by the same physician.The corneal endothelial cells on the upper,the central and the lower corneal were measured by using corneal endothelial microscope preoperative and 1 week,1 month and 3 months postoperative.The comeal endothelial cells density,loss rate,hexagonal cell ratio and cell area were calculated. Results The differences among the upper,the central and the lower cornea of comcal endothelial cells density,hexagonal cell ratio and cell area were no statistical significances (all P ＞0.05) before operation.The comeal endothelial cells density decreased,the hexagonal cells ratio decreased and the cell area increased after operation.The differences among the upper,the central and the lower cornea of corneal endothelial cells density,hexagonal cell ratio and cell area were the largest at 1 week after operation and were statistical significances (all P ＜0.01).The differences among the upper,the central and the lower cornea of corneal endothelial cells density,hexagonal cell ratio and cell area were statistical significances at 1month after operation (all P ＜0.05).The differences among the upper,the central and the lower corneal of corneal endothelial cells density,hexagonal cell ratio and cell area were no statistical significances at 3 months after operation (all P ＞0.05). Conclusions Small incision nonphacoemulsification cataract extraction has a small amount of damage on corneal endothelial cells,and the damage position is mainly at the incision on the upper part of corneal.