中华结核和呼吸杂志
中華結覈和呼吸雜誌
중화결핵화호흡잡지
Chinese Journal of Tuberculosis and Respiratory Diseases
2009年
10期
748-751
,共4页
赵真真%张天哲%高永明%冯福民
趙真真%張天哲%高永明%馮福民
조진진%장천철%고영명%풍복민
结核%多态现象%遗传%受体%骨化三醇%Meta分析
結覈%多態現象%遺傳%受體%骨化三醇%Meta分析
결핵%다태현상%유전%수체%골화삼순%Meta분석
Tuberculosis%Polymorphism%genetic%Receptors%calcitriol%Meta-analysis
目的 应用荟萃分析探讨维生素D受体(VDR)基因FokI、TaqI多态性与结核易感性的关系.方法 在中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方数据资源系统、MEDLINE和PubMed中,应用关键词"结核"、"基因多态性"或"遗传多态性"、"等位基因"、"VDR"、"tuberculosis"或"alleles"搜索1980年1月至2007年11月发表的相关中英文文献,最终入选文献14篇.应用RevMan4.2软件包分别对14项研究结果进行数据分析.结果 荟萃分析计算得出合并OR值(95%CI):Ff/FF基因型为1.12(0.98～1.28),ff/FF基因型为1.66(1.12～2.46),Tt/TT基因型为0.97(0.82～1.14),tt/TT基因型为1.27(0.96～1.69).计算FokI基因的失安全系数为109.69,TaqI基因的失安全系数为75.24,说明分析结果可靠.结论 维生素D受体基因FokI多态性与结核易感性有关,TaqI多态性与结核易感性尚无明确关系.
目的 應用薈萃分析探討維生素D受體(VDR)基因FokI、TaqI多態性與結覈易感性的關繫.方法 在中國知網(CNKI)、中國生物醫學文獻數據庫(CBM)、萬方數據資源繫統、MEDLINE和PubMed中,應用關鍵詞"結覈"、"基因多態性"或"遺傳多態性"、"等位基因"、"VDR"、"tuberculosis"或"alleles"搜索1980年1月至2007年11月髮錶的相關中英文文獻,最終入選文獻14篇.應用RevMan4.2軟件包分彆對14項研究結果進行數據分析.結果 薈萃分析計算得齣閤併OR值(95%CI):Ff/FF基因型為1.12(0.98～1.28),ff/FF基因型為1.66(1.12～2.46),Tt/TT基因型為0.97(0.82～1.14),tt/TT基因型為1.27(0.96～1.69).計算FokI基因的失安全繫數為109.69,TaqI基因的失安全繫數為75.24,說明分析結果可靠.結論 維生素D受體基因FokI多態性與結覈易感性有關,TaqI多態性與結覈易感性尚無明確關繫.
목적 응용회췌분석탐토유생소D수체(VDR)기인FokI、TaqI다태성여결핵역감성적관계.방법 재중국지망(CNKI)、중국생물의학문헌수거고(CBM)、만방수거자원계통、MEDLINE화PubMed중,응용관건사"결핵"、"기인다태성"혹"유전다태성"、"등위기인"、"VDR"、"tuberculosis"혹"alleles"수색1980년1월지2007년11월발표적상관중영문문헌,최종입선문헌14편.응용RevMan4.2연건포분별대14항연구결과진행수거분석.결과 회췌분석계산득출합병OR치(95%CI):Ff/FF기인형위1.12(0.98～1.28),ff/FF기인형위1.66(1.12～2.46),Tt/TT기인형위0.97(0.82～1.14),tt/TT기인형위1.27(0.96～1.69).계산FokI기인적실안전계수위109.69,TaqI기인적실안전계수위75.24,설명분석결과가고.결론 유생소D수체기인FokI다태성여결핵역감성유관,TaqI다태성여결핵역감성상무명학관계.
Objectives To provide a quantitative summary in estimating the association between polymorphisms of 2 loci of FokI and TaqI in vitamin D receptor gene and susceptibility to tuberculosis by means of recta-analysis. Methods Databases CNKI, CBM, WanFang DATA, MEDLINE and PubMed were searched using "VDR", "polymorphisms" or "alleles", in combination with "tuberculosis", and a manual search of citations from relevant original studies and literature between January 1980 and November 2007 was also performed. RevMan 4.2 was applied in the process of analyzing the data of 14 case-control studies. Results The summary ORs for studies with polymorphisms of FokI, TaqI loci of the VDR gene were 1.12 (95%CI: 0.98-1.28) in Ff vs FF, 1.66 (95%CI: 1.12-2.46) in ff vs FF, 0.97 (95%CI: 0.82-1.14) in Tt vs TT, 1.27 (95% CI: 0.96-1.69) in tt vs TT. The fail-safe number was 109.69 for FokI and 75.24 for TaqI. The analysis result was reliable. Conclusions Polymorphisms at FokI loci (VDR-ff) showed statistically significant association between the VDR variants and susceptibility to tuberculosis, and variant in the TaqI locus failed to show statistically significant association.
