CAJ | 학술논문

本文报道应用大剂量环已亚硝脲(CCNU)辅以自身骨髓移植治疗小儿脑肿瘤22例.分三组采用不同方案治疗,均能渡过药物所致骨髓抑制期,可以延长小儿脑部恶性肿瘤手术后的生存期,并有可能获得痊愈.
본문보도응용대제량배이아초뇨(CCNU)보이자신골수이식치료소인뇌종류22례.분삼조채용불동방안치료,균능도과약물소치골수억제기,가이연장소인뇌부악성종류수술후적생존기,병유가능획득전유.
From 1980 to 1985,we used large dosage of CCNU plus auto-bonemarrow transplantation to treat brain tumours in children,including madullablastoma(10cases),epondymoma(5),hemisphere astrocytoblastoma(4),cerebellar astrocytoblastoma(1),brain stem tumour(2).These cases were divided into 3 groups and were given different treatments.In group Ⅰ(6 cases),oral medication of CCNU 260-390mg/m~2,(2-3 times as much as the routine dosage of 100 mg/m~2)plus autobonemarrow transplantation was used.A middle survival stage of 10 months was achieved.In group Ⅱ(6 cases),the same treatment as in Group Ⅰ was used but thereafter routine dosage of CCNU was continued for 6 months.This group sees a middle survival stage of 15 months.In group Ⅲ(10 cases),in addition to the treatment used in Group Ⅱ,vascrine(2 mg/m~2/w)was also given intravenously.The middle survival stage has beed 20 months,by now,and no death has been reported yet.CT scanning of 5 of the cases revealed no tumours.Conclusion:Auto-bonemarrow transplantation can help the patients tide over the bone marrow depression period caused by CCUN in toxication and have a longer postoperative survival time,and it even makes cure possible.