CAJ | 학술논문

目的探讨唑来膦酸联合局部放疗治疗恶性肿瘤局限件骨转移的临床疗效.方法 45例局限性骨转移患者随机分为2组,联合治疗组23例,采用唑来膦酸静脉滴注加局部放疗;单纯放疗组22例,只采用局部放疗.结果联合治疗组和单纯放疗组的疼痛缓解率分别为91.3%和86.4%.差异无统计学意义(P>0.05);联合治疗组和单纯放疗组的溶骨病灶再钙化的有效率分别为52.2%和22.7%,差异有统计学意义(P<0.01);联合治疗组和单纯放疗组出现新的骨转移病灶的患者比例分别为13.0%和40.9%,联合治疗组显著低于单纯化疗组(P<0.05).联合治疗组的不良反应主要为短暂低热和恶心.结论唑来膦酸联合放疗治疗恶性肿瘤局限性骨转移疗效确切,其控制骨痛作用强,可高效修复溶骨病灶,并能降低新的骨转移灶发生率.
목적 탐토서래련산연합국부방료치료악성종류국한건골전이적림상료효.방법 45례국한성골전이환자수궤분위2조,연합치료조23례,채용서래련산정맥적주가국부방료;단순방료조22례,지채용국부방료.결과 연합치료조화단순방료조적동통완해솔분별위91.3%화86.4%.차이무통계학의의(P>0.05);연합치료조화단순방료조적용골병조재개화적유효솔분별위52.2%화22.7%,차이유통계학의의(P<0.01);연합치료조화단순방료조출현신적골전이병조적환자비례분별위13.0%화40.9%,연합치료조현저저우단순화료조(P<0.05).연합치료조적불량반응주요위단잠저열화악심.결론 서래련산연합방료치료악성종류국한성골전이료효학절,기공제골통작용강,가고효수복용골병조,병능강저신적골전이조발생솔.
Objective To evaluate the efficacy of zoledronic acid combined with local radiotherapy for limited metastatic bone cancer. Methods Forty-five patients with limited bone metastatic cancers were randomly divided into two groups: 23 in the combination group who received intravenously administration of zoledronic acid and local radiotherapy, the other 22 in the radiotherapy alone group who underwent local radiotherapy only. Results The response rate of pain relief was 91.3% in the combination group versus 86.4% in the radiotherapy alone group, without statistically significant difference between two groups (P >0.05 ). However, the recalcification rate was significantly higher in the combination therapy group (52.2%) than that in radiotherapy alone group (22.7% ,P <0.01 ), and the proportion of patients with new bone metastasis formation was significantly lower in the combination group ( 13.0% ) than that in theradiotherapy alone group (40.9% ,P <0.05 ). The common side-effects were transient pyrexia and nausea.Conclusion Zoledronic acid combined with local radiotherapy is effective in relieving pain, improving bone recalcification and reducing the formation of new bone metastasis.