中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2011年
4期
373-377
,共5页
新生血管化,病理性%选择性剪接%血管内皮生长因子A%血管生成抑制剂
新生血管化,病理性%選擇性剪接%血管內皮生長因子A%血管生成抑製劑
신생혈관화,병이성%선택성전접%혈관내피생장인자A%혈관생성억제제
Neovascularization,pathologic%Alternative splicing%Vascular endothelial growth factor A%Angiogenesis inhibitors
眼内新生血管的生成是多种眼病致盲的重要原因.血管内皮生长因子A(VEGF-A)家族是促进眼内新生血管生成的关键因素,其通过调控病理性血管的发生和增加血管的通透性而起作用.VEGF-A依选择性剪接方式的不同,可形成2个蛋白家族,分别是具有促血管生成作用的VEGFxxx家族和具有抗血管生成作用的VEGFxxxb家族.VEGFxxxb家族蛋白在正常眼组织中均有表达,而在糖尿病性视网膜病变患者的眼组织中表达水平降低.VEGF165b是VEGFxxxb家族中最早分离出来且研究最为广泛的分子结构,其可以明显抑制视网膜前新生血管的生成,而对视网膜生理性血管的发生无抑制作用.随着对VEGFxxxb家族研究的逐步深入,选择性剪接调节VEGFxxx与VEGFxxxb两者之间的平衡,可作为糖尿病性视网膜病变、年龄相关性黄斑变性等眼内新生血管性疾病的治疗新策略.
眼內新生血管的生成是多種眼病緻盲的重要原因.血管內皮生長因子A(VEGF-A)傢族是促進眼內新生血管生成的關鍵因素,其通過調控病理性血管的髮生和增加血管的通透性而起作用.VEGF-A依選擇性剪接方式的不同,可形成2箇蛋白傢族,分彆是具有促血管生成作用的VEGFxxx傢族和具有抗血管生成作用的VEGFxxxb傢族.VEGFxxxb傢族蛋白在正常眼組織中均有錶達,而在糖尿病性視網膜病變患者的眼組織中錶達水平降低.VEGF165b是VEGFxxxb傢族中最早分離齣來且研究最為廣汎的分子結構,其可以明顯抑製視網膜前新生血管的生成,而對視網膜生理性血管的髮生無抑製作用.隨著對VEGFxxxb傢族研究的逐步深入,選擇性剪接調節VEGFxxx與VEGFxxxb兩者之間的平衡,可作為糖尿病性視網膜病變、年齡相關性黃斑變性等眼內新生血管性疾病的治療新策略.
안내신생혈관적생성시다충안병치맹적중요원인.혈관내피생장인자A(VEGF-A)가족시촉진안내신생혈관생성적관건인소,기통과조공병이성혈관적발생화증가혈관적통투성이기작용.VEGF-A의선택성전접방식적불동,가형성2개단백가족,분별시구유촉혈관생성작용적VEGFxxx가족화구유항혈관생성작용적VEGFxxxb가족.VEGFxxxb가족단백재정상안조직중균유표체,이재당뇨병성시망막병변환자적안조직중표체수평강저.VEGF165b시VEGFxxxb가족중최조분리출래차연구최위엄범적분자결구,기가이명현억제시망막전신생혈관적생성,이대시망막생이성혈관적발생무억제작용.수착대VEGFxxxb가족연구적축보심입,선택성전접조절VEGFxxx여VEGFxxxb량자지간적평형,가작위당뇨병성시망막병변、년령상관성황반변성등안내신생혈관성질병적치료신책략.
Ocular neovascularization is the primary cause of blindness in a wide range of ocular diseases. The vascular endothelial growth factor A (VEGF-A) is the key factor involved in ocular angiogenesis, which can cause eye diseases through the development of pathological angiogenesis and increase of vascular permeability. There are two families of VEGF-A isoforms formed by alternative splicing,the angiogenic VEGF-A family ( VEGFxxx ), known to contribute to ocular neovascularization, and the antiangiogenic VEGF-A family ( VEGFxxx b), which is found in normal ocular tissues but downregulated in human diabetic retinopathy. The first member of the VEGFxxxb family to be isolated was VEGF165b. It can significantly reduce preretinal neovascularization without inhibition of physiological intraretinal angiogenesis.As the studies on the VEGFxxxb family proceed more deeply, controlling the balance of VEGFxxx to VEGFxxxb isoforms may be therapeutically valuable in the treatment of angiogenic eye diseases such as diabetic retinopathy and age-related macular degeneration.
