CAJ | 학술논문

小RNA的发现为基因调控系统研究提供了新的方向.在多数物种中已经发现了大量的小RNA.这一领域已经成为了近来研究的热点,在研究起始阶段,计算学方法已经成为实验研究中不可或缺的工具,许多发现是由生物学实验与计算学方法共同合作来完成的.总结了前人关于小RNA及其靶基因识别的理论知识,讨论了关于预测小RNA及其靶基因的计算学方法和相关软件.
소RNA적발현위기인조공계통연구제공료신적방향.재다수물충중이경발현료대량적소RNA.저일영역이경성위료근래연구적열점,재연구기시계단,계산학방법이경성위실험연구중불가혹결적공구,허다발현시유생물학실험여계산학방법공동합작래완성적.총결료전인관우소RNA급기파기인식별적이론지식,토론료관우예측소RNA급기파기인적계산학방법화상관연건.
The discovery of microRNAs (miRNAs) has introduced a new paradigm into gene regulatory systems. Since inception, computational methods have been an invaluable tool complementing experimental approaches, and many discoveries have been obtained through combination of experimental and computational approaches. The knowledge that has been accumulated about the principles of miRNAs and target recognition were reviewed. The currently available computational methodologies and software for prediction of miRNA and their target genes also have been discussed.