CAJ | 학술논문

作为新一代基因诊断技术,DNA芯片已广泛应用于肺癌分子分类、基因表达和分子通路的病理变异分析、预后及转移监测、个体化治疗和药物开发等.基于技术差异、不同患者人群和生物多样性等因素,目前DNA芯片发展的主要障碍为缺乏机械性、可靠性和可重复性.冀望借着更好的标准化和分析手段,利用高维数据分析方法来减少噪音,未来DNA芯片技术或能实际应用于肺癌的个体化诊疗.
작위신일대기인진단기술,DNA심편이엄범응용우폐암분자분류、기인표체화분자통로적병리변이분석、예후급전이감측、개체화치료화약물개발등.기우기술차이、불동환자인군화생물다양성등인소,목전DNA심편발전적주요장애위결핍궤계성、가고성화가중복성.기망차착경호적표준화화분석수단,이용고유수거분석방법래감소조음,미래DNA심편기술혹능실제응용우폐암적개체화진료.
DNA expression profiling using microarray technology has been applied to studies on the molecular classification of lung cancers, pathogenetic alterations in gene expressions and cellular path-ways, prediction of prognosis and metastasis, customized therapies, and drug development. Due to the wide variation in technical factors, different cohorts of patients and biological heterogeneity, the major hur-dle to successful clinical application is lack of robustness, reliability and reproducibility of data. With better standardization and better analytic approaches to cut down the noises from the high dimensionality of data, microarray technologies may be ready to make its way to the doctor's office with contribution to personal-ized treatment of lung cancer in the future.