CAJ | 학술논문

作为胰高血糖素样肽-1(GLP-1)的受体激动剂,艾塞那肽具有促进葡萄糖依赖的胰岛素分泌、抑制胰高血糖素分泌、增加胰岛素敏感性、延缓胃排空、降低食欲及食物摄人等作用.临床研究显示,艾塞那肽可显著降低2型糖尿病患者糖化血红蛋白( Hb) A1c、空腹血糖、餐后血糖水平并减轻患者体重,且对2型糖尿病心血管并发症有益.基于其独特的降糖模式,艾塞那肽已成为2型糖尿病治疗的新靶点.
작위이고혈당소양태-1(GLP-1)적수체격동제,애새나태구유촉진포도당의뢰적이도소분비、억제이고혈당소분비、증가이도소민감성、연완위배공、강저식욕급식물섭인등작용.림상연구현시,애새나태가현저강저2형당뇨병환자당화혈홍단백( Hb) A1c、공복혈당、찬후혈당수평병감경환자체중,차대2형당뇨병심혈관병발증유익.기우기독특적강당모식,애새나태이성위2형당뇨병치료적신파점.
Exenatide,a glucagon-like peptide-1 ( GLP-1 ) receptor agonist,can stimulate insulin secretion in a glucose-dependent manner,inhibit glucagon secretion and increase insulin sensitivity,inhibit gastric emptying,reduce appetite and food intake.Clinical studies with exenatide have shown a significant reduction in HbAlc,fasting and postprandial glucose,body weight,and cardiovascular complications of type 2 diabetes.Due to its special therapeutic efficacy,exenatide represent a new and innovative treatment modality in the management of type 2 diabetes.