中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
18期
6-8
,共3页
甲氨蝶呤%米非司酮%腹腔镜%妊娠,异位
甲氨蝶呤%米非司酮%腹腔鏡%妊娠,異位
갑안접령%미비사동%복강경%임신,이위
Methotrexate%Mifepristone%Laparoscopes%Pregnancy,ectopic
目的 探讨输卵管妊娠腹腔镜保守性手术术前应用米非司酮和术后应用甲氨蝶呤联合米非司酮预防持续性异位妊娠(PEP)的疗效.方法 将120例输卵管妊娠患者按住院号分为两组:研究组(60例)术前口服米非司酮后行腹腔镜保守性手术,术后应用米非司酮联合甲氨蝶呤;对照组(60例)行单纯腹腔镜保守性手术.观察两组术中出血量,均于术前及术后1、3、7、12 d检测血β-人绒毛膜促性腺激素(β-hCG)水平,并进行比较.结果 两组术后3、7、12 d血β-hCG水平比较差异有统计学意义(P<0.05).研究组术中出血量[(21.8±2.2)ml]明显少于对照组[(38.1±3.1)ml](P<0.05).研究组无一例发生PEP,对照组有2例(3.33%,2/60)发生PEP.结论 术前应用米非司酮和术后应用米非司酮联合甲氨蝶呤用于防治输卵管妊娠腹腔镜保守性手术后PEP的疗效明显,与单纯行腹腔镜保守性手术相比有优势,临床上可以选择此种方法.
目的 探討輸卵管妊娠腹腔鏡保守性手術術前應用米非司酮和術後應用甲氨蝶呤聯閤米非司酮預防持續性異位妊娠(PEP)的療效.方法 將120例輸卵管妊娠患者按住院號分為兩組:研究組(60例)術前口服米非司酮後行腹腔鏡保守性手術,術後應用米非司酮聯閤甲氨蝶呤;對照組(60例)行單純腹腔鏡保守性手術.觀察兩組術中齣血量,均于術前及術後1、3、7、12 d檢測血β-人絨毛膜促性腺激素(β-hCG)水平,併進行比較.結果 兩組術後3、7、12 d血β-hCG水平比較差異有統計學意義(P<0.05).研究組術中齣血量[(21.8±2.2)ml]明顯少于對照組[(38.1±3.1)ml](P<0.05).研究組無一例髮生PEP,對照組有2例(3.33%,2/60)髮生PEP.結論 術前應用米非司酮和術後應用米非司酮聯閤甲氨蝶呤用于防治輸卵管妊娠腹腔鏡保守性手術後PEP的療效明顯,與單純行腹腔鏡保守性手術相比有優勢,臨床上可以選擇此種方法.
목적 탐토수란관임신복강경보수성수술술전응용미비사동화술후응용갑안접령연합미비사동예방지속성이위임신(PEP)적료효.방법 장120례수란관임신환자안주원호분위량조:연구조(60례)술전구복미비사동후행복강경보수성수술,술후응용미비사동연합갑안접령;대조조(60례)행단순복강경보수성수술.관찰량조술중출혈량,균우술전급술후1、3、7、12 d검측혈β-인융모막촉성선격소(β-hCG)수평,병진행비교.결과 량조술후3、7、12 d혈β-hCG수평비교차이유통계학의의(P<0.05).연구조술중출혈량[(21.8±2.2)ml]명현소우대조조[(38.1±3.1)ml](P<0.05).연구조무일례발생PEP,대조조유2례(3.33%,2/60)발생PEP.결론 술전응용미비사동화술후응용미비사동연합갑안접령용우방치수란관임신복강경보수성수술후PEP적료효명현,여단순행복강경보수성수술상비유우세,림상상가이선택차충방법.
Objective To investigate the efficacy of methotrexate combined with mifepristone prophylaxis for persistent ectopic pregnancy (PEP) after laparoscopic conservative surgery. Methods One hundred and twenty cases of tubal pregnancy were randomly divided into two groups by admission number, the study group (60 cases) were treated by mifepristone before laparoscopic conservative surgery and methotrexate combined with mifepristone after laparoscopic conservative surgery, but the control group (60 cases) were treated by laparoscopic conservative surgery, the bleeding was observated in the surgery,concentration of β-human chorionic gonadotrop ( β-hCG) was detected before operation and 1,3,7,12 d after operation. Results There were significant differences in β-hCG after operation 3,7,12 d between two groups(P<0.05). The bleeding was (21.8 ?.2) ml in study group,and (38.1 ?3.1) ml in control group, there was significant difference between two groups (P<0.05). In study group, the incidence of PEP was 0, and 3.33%(2/60) in control group. Conclusion Preoperative mifepristone and postoperative mifepristone combined with methotrexate in preventing PEP after laparoscopic conservative surgery is efficacy, and it can be chosen in clinic.
