中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
3期
199-202
,共4页
卒中后抑郁%认知功能%载脂蛋白E%基因多态性
卒中後抑鬱%認知功能%載脂蛋白E%基因多態性
졸중후억욱%인지공능%재지단백E%기인다태성
Post-stroke depression%Cognitive impairment%Apolipoprotein E%Gene polymorphism
目的 探讨卒中后抑郁患者( post-stroke depression,PSD)认知功能损害与ApoE基因多态性之间的相关性.方法 根据24项汉密尔顿抑郁量表(HAMD-24)评分将患者分为PSD组(83例)和卒中组(96例),选取健康志愿者(53例)作为对照组.采用事件相关电位( ERP) P300作为认知功能的评定指标.采用基因测序法测定载脂蛋白E基因第四外显子112位( rs429358)和158位(rs7412)单核苷酸位点多态性.结果 1.EPR测定卒中后抑郁组N2、P3波潜伏期较卒中组和对照组延长,P3波幅降低,差异有统计学意义(P＜0.05).2.PSD组ε3/ε4基因型频数(24例)高于对照组(7例),ε4/4基因频数(8例)高于卒中组(2例),差异有统计学意义(P＜0.05)；ε4等位基因频率(24.7％)高于卒中组(16.1％)和对照组(9.4％),差异有统计学意义(P＜0.05).3.PSD组携带ε4等位基因的HAMD-24评分、N2潜伏期、P3潜伏期高于非携带ε4等位基因组,差异有统计学意义(P＜0.05).结论 PSD患者存在认知功能损害,ε4等位基因可能与PSD患者的认知功能损害和抑郁情绪具有一定相关性.
目的 探討卒中後抑鬱患者( post-stroke depression,PSD)認知功能損害與ApoE基因多態性之間的相關性.方法 根據24項漢密爾頓抑鬱量錶(HAMD-24)評分將患者分為PSD組(83例)和卒中組(96例),選取健康誌願者(53例)作為對照組.採用事件相關電位( ERP) P300作為認知功能的評定指標.採用基因測序法測定載脂蛋白E基因第四外顯子112位( rs429358)和158位(rs7412)單覈苷痠位點多態性.結果 1.EPR測定卒中後抑鬱組N2、P3波潛伏期較卒中組和對照組延長,P3波幅降低,差異有統計學意義(P＜0.05).2.PSD組ε3/ε4基因型頻數(24例)高于對照組(7例),ε4/4基因頻數(8例)高于卒中組(2例),差異有統計學意義(P＜0.05)；ε4等位基因頻率(24.7％)高于卒中組(16.1％)和對照組(9.4％),差異有統計學意義(P＜0.05).3.PSD組攜帶ε4等位基因的HAMD-24評分、N2潛伏期、P3潛伏期高于非攜帶ε4等位基因組,差異有統計學意義(P＜0.05).結論 PSD患者存在認知功能損害,ε4等位基因可能與PSD患者的認知功能損害和抑鬱情緒具有一定相關性.
목적 탐토졸중후억욱환자( post-stroke depression,PSD)인지공능손해여ApoE기인다태성지간적상관성.방법 근거24항한밀이돈억욱량표(HAMD-24)평분장환자분위PSD조(83례)화졸중조(96례),선취건강지원자(53례)작위대조조.채용사건상관전위( ERP) P300작위인지공능적평정지표.채용기인측서법측정재지단백E기인제사외현자112위( rs429358)화158위(rs7412)단핵감산위점다태성.결과 1.EPR측정졸중후억욱조N2、P3파잠복기교졸중조화대조조연장,P3파폭강저,차이유통계학의의(P＜0.05).2.PSD조ε3/ε4기인형빈수(24례)고우대조조(7례),ε4/4기인빈수(8례)고우졸중조(2례),차이유통계학의의(P＜0.05)；ε4등위기인빈솔(24.7％)고우졸중조(16.1％)화대조조(9.4％),차이유통계학의의(P＜0.05).3.PSD조휴대ε4등위기인적HAMD-24평분、N2잠복기、P3잠복기고우비휴대ε4등위기인조,차이유통계학의의(P＜0.05).결론 PSD환자존재인지공능손해,ε4등위기인가능여PSD환자적인지공능손해화억욱정서구유일정상관성.
Objective To study and analyze the relation between cognitive impairment and apolipoprotein E(ApoE) gene polymorphism in post-stroke depression patients(PSD).Methods The patients were divided into PSD group(83 cases) and brain stroke group(96 cases) by using the 24-item Hamilton Depression Rating Scale (HAMD-24),and healthy volunteers were selected as a control group(53 cases).Cognitive function was evaluated by using the event-related potential (ERP) P300 and single nucleotide polymorphisms of ApoE exon 4 of 112 (rs429358) and 158 (rs7412) were determined by using gene sequencing method.Results 1.Compared with the brain stroke group and the control group,latency in ERP including N2 and P3 of PSD group was significantly prolonged (P＜ 0.05 ),while the amplitude of P3 in PSD was significantly lower(P＜ 0.05 ).2.e3/ε4 genotype frequency in PSD group(24 cases) was significantly higher than that in the control group(7 cases) (P＜0.05).The e4/4 genotype fiequency in PSD group (8 cases) was significantly higher than that in brain stroke group (2 cases) (P ＜ 0.05 ).The e4 allele rate in PSD group ( 24.7％ ) was significantly higher than that in both brain stroke group (16.1％) and contro] group(9.4％ ) (all P＜0.05).3.The PSD patients with ε4 allele had significantly higher score of HAMD-24 and prolonged latency of N2 and P3 than those without e4 allele (P ＜ 0.05 ).Conclusion There is cognitive impairment in PSD patients.The ApoE ε4 allele may associate with the cognitive impairment and depression in PSD patients.
