CAJ | 학술논문

目的探讨环氧化物水解酶( EPHX2)基因rs751141位点基因多态性与新疆哈萨克族、汉族原发性高血压之间的相关性.方法分别选择新疆哈萨克族267例,汉族原发性高血压患者368例,同时选取哈萨克族、汉族正常对照组284例和348例,用Hardy-Weinberg平衡检验样本群体代表性,采用TaqMan探针法对EPHX2基因rs751141位点基因多态性进行检测.结果新疆汉族原发性高血压组rs751141G/A多态位点GA+ AA基因型的分布频率(40.2％)明显低于正常对照组(52.0％),差异具有统计学意义(P＜0.01),而新疆哈萨克族原发性高血压组与正常对照组中rs751141G/A基因多态性比较差异均无统计学意义(P＞0.05).结论 EPHX2基因rs751141 G/A等位基因多态性与新疆哈萨克族原发性高血压无显著相关性,EPHX2基因rs751141G/A等位基因多态性与新疆汉族原发性高血压均显著相关,EPHX2基因rs751141位点的A等位基因可能是新疆汉族原发性高血压病的独立的保护因子.
목적 탐토배양화물수해매( EPHX2)기인rs751141위점기인다태성여신강합살극족、한족원발성고혈압지간적상관성.방법 분별선택신강합살극족267례,한족원발성고혈압환자368례,동시선취합살극족、한족정상대조조284례화348례,용Hardy-Weinberg평형검험양본군체대표성,채용TaqMan탐침법대EPHX2기인rs751141위점기인다태성진행검측.결과 신강한족원발성고혈압조rs751141G/A다태위점GA+ AA기인형적분포빈솔(40.2％)명현저우정상대조조(52.0％),차이구유통계학의의(P＜0.01),이신강합살극족원발성고혈압조여정상대조조중rs751141G/A기인다태성비교차이균무통계학의의(P＞0.05).결론 EPHX2기인rs751141 G/A등위기인다태성여신강합살극족원발성고혈압무현저상관성,EPHX2기인rs751141G/A등위기인다태성여신강한족원발성고혈압균현저상관,EPHX2기인rs751141위점적A등위기인가능시신강한족원발성고혈압병적독립적보호인자.
Objective To investigate the association between rs751141 gene polymorphisms in EPHX2 gene and essential hypertension in Kazak and Han in Xinjiang.MethodsA total of 267 essential hypertensive patients in Kazaks,368 essential hypertensive patients in Hans,284 normotensive controls in Kazaks and 348 normotensive controls in Hans were enrolled in this study.TaqMan assay was used to detect the rs751141 G/A gene polymorphisms of EPHX2 gene.Results The rs751141 G/A genotype frequencies for GA + AA genotypes was 40.2 percent in essential hypertensive subjects and 52.0 percent in control subjects in Hans,respectively.The genotype frequencies were significant difference between the two groups in Hans in Xinjiang( P ＜ 0.01 ).The rs751141G/A gene polymorphism had no significant difference between essential hypertensive patients and normotensive controls in Kazaks in Xinjiang(P＞0.05).Conclusion The essential hypertension in Kazaks in Xinjiang is not associated with rs751141G/A gene polymorphism of EPHX2 gene,but the essential hypertension in Hans in Xinjiang is associated with rs751141G/A allele gene polymorphism of EPHX2 gene.A type of rs751141 allele gene polymorphism may be the independent protective factor of essential hypertension in Hans in Xiniiang.