天津中医药
天津中醫藥
천진중의약
TIANJIN JOURNAL OF TRADITIONAL CHINESE MEDICINE
2004年
4期
343-345
,共3页
药物相互作用%芍药甘草汤%甘草酸%药动学
藥物相互作用%芍藥甘草湯%甘草痠%藥動學
약물상호작용%작약감초탕%감초산%약동학
drug-drug interaction%Shaoyao-Gancao-Tang%glycyrrhizin%pharmacokinetics
芍药甘草汤(SGT)是常用中药方剂之一,在日本临床上常和一些西药合用.甘草酸(glycyrrhizin,GL)是SGT中主要的有效配糖体成分之一,经口给药后,GL在肠道内被肠内细菌代谢成活性产物甘草次酸(18β-glycyrrhetic acid,GA).本研究旨在利用大鼠,以GA的血药浓度为指标,探讨合用西药对SGT中GL的生物利用度的影响以及减少该影响的给药方案.笔者在本部分中首先考察了SGT中GL生物利用度在SGT连续给药下的变化.实验结果显示,GL生物利用度随着SGT的连续给药而逐渐上升.
芍藥甘草湯(SGT)是常用中藥方劑之一,在日本臨床上常和一些西藥閤用.甘草痠(glycyrrhizin,GL)是SGT中主要的有效配糖體成分之一,經口給藥後,GL在腸道內被腸內細菌代謝成活性產物甘草次痠(18β-glycyrrhetic acid,GA).本研究旨在利用大鼠,以GA的血藥濃度為指標,探討閤用西藥對SGT中GL的生物利用度的影響以及減少該影響的給藥方案.筆者在本部分中首先攷察瞭SGT中GL生物利用度在SGT連續給藥下的變化.實驗結果顯示,GL生物利用度隨著SGT的連續給藥而逐漸上升.
작약감초탕(SGT)시상용중약방제지일,재일본림상상상화일사서약합용.감초산(glycyrrhizin,GL)시SGT중주요적유효배당체성분지일,경구급약후,GL재장도내피장내세균대사성활성산물감초차산(18β-glycyrrhetic acid,GA).본연구지재이용대서,이GA적혈약농도위지표,탐토합용서약대SGT중GL적생물이용도적영향이급감소해영향적급약방안.필자재본부분중수선고찰료SGT중GL생물이용도재SGT련속급약하적변화.실험결과현시,GL생물이용도수착SGT적련속급약이축점상승.
Shaoyao-Gancao-Tang (SGT), a traditional Chinese prescription, is sometimes used together with some synthetic drugs in Japan. Glycyrrhizin (GL) is a major active glycoside ingredient in SGT and is biotrans formed into a bioactive metabolite, 18 β-glycyrrhetic acid (GA), by intestinal bacteria in the gut after being orally administered. In this study, the effects of the co-administered synthetic drugs on the bioavailability of GL (plasma GA concentration) were investigated in rats. The alterations of bioavailability of GL from repetitive administration of SGT were examined. The results showed that the plasma concentration of GA was gradually elevated by the repetitive administration of GST.
