CAJ | 학술논문

目的探讨血管内皮生长因子C(vascular endothelial growth factor C,VEGF-C)在胰腺癌淋巴管生成及其与淋巴结转移中的作用.方法采用免疫组织化学染色法,检测42例胰腺癌组织标本和10例正常胰腺组织标本的VEGF-C表达;应用酶组织化学方法检测癌周微淋巴管密度(microlymphatic vessel density,MLVD).结果胰腺癌VEGF-C的阳性表达率为64.3%,显著高于正常对照组的20%(P＜0.05);胰腺癌MLVD为21.93±6.39,显著高于正常对照组的4.40±2.07(P＜0.001),VEGF-C表达与肿瘤组织MLVD及淋巴结转移呈正相关(P＜0.05).结论VEGF-C在胰腺癌淋巴管生成及其淋巴结转移中具有重要作用.
목적탐토혈관내피생장인자C(vascular endothelial growth factor C,VEGF-C)재이선암림파관생성급기여림파결전이중적작용.방법채용면역조직화학염색법,검측42례이선암조직표본화10례정상이선조직표본적VEGF-C표체;응용매조직화학방법검측암주미림파관밀도(microlymphatic vessel density,MLVD).결과이선암VEGF-C적양성표체솔위64.3%,현저고우정상대조조적20%(P＜0.05);이선암MLVD위21.93±6.39,현저고우정상대조조적4.40±2.07(P＜0.001),VEGF-C표체여종류조직MLVD급림파결전이정정상관(P＜0.05).결론VEGF-C재이선암림파관생성급기림파결전이중구유중요작용.
Objective: To investigate the role the vascular endothelial growth factor C (VEGF-C) expression in lymphangiogenesis and lymph node metastasis in pancreatic cancer. Methods: The expression of VEGF-C in pancreatic cancer tissue of 42 cases and normal pancreatic tissue of 10 cases was detected by using immunohistochemical S-P method. The microlymphatic vessel density (MLVD) of both tissues was measured by enzyme-histochemical method at the same time. Results: The VEGF-C positive expression rate was significantly higher in pancreatic cancer tissue (64.3%) than in normal pancreatic tissue (20%,P＜0.05). The MLVD was significantly higher in pancreatic cancer tissue (21.93±6.39) than that in normal pancreatic tissue (4.40±2.07, P＜0.001). The VEGF-C positive expression rate, MLVD and lymph node metastasis had a positive correlation. Conclusion: The VEGF-C may play an important role in the lymphangiogenesis and lymph node metastasis of pancreatic cancer.