CAJ | 학술논문

目的应用事件相关电位技术探讨8 h恢复性睡眠对36 h完全睡眠剥夺后大脑执行功能的影响.方法 13名健康男性大学生参加正常睡眠和36 h睡眠剥夺两次试验,睡眠剥夺后受试者接受8 h恢复性睡眠.每次试验中受试者共接受6次Go/Nogo测验,同时记录行为学及ERP数据.结果正常睡眠时,受试者的行为学及ERP指标在各个时间点上均无统计学差异.36 h睡眠剥夺后,行为学指标与基线值相比有统计学差异;Fz电极Nogo-N2、Nogo-P3及Cz电极Nogo-P3的波幅、潜伏期与基线值相比有统计学差异.8 h恢复性睡眠后,平均正确反应时、Go正确反应率与36 h睡眠剥夺值相比有统计学差异;Fz电极Nogo-N2、Nogo-P3及Cz电极Nogo-P3的波幅与基线值相比无统计学差异,但与36 h睡眠剥夺值相比[(-6.80±3.95)与(-3.37±2.63)μV,(10.63±6.62)与(5.63±5.45)μV,(9.49±7.37)与(6.08±6.56)μV]有统计学差异;其潜伏期与基线值的差异[(254.14±15.55)与(243.08±13.97) ms,(382.14±41.07)与(349.17±30.36) ms,(369.86±26.48)与(347.48±29.24) ms]有统计学意义.结论睡眠剥夺损害了大脑的执行功能,这种损害随剥夺时间的延长而加重.8 h恢复性睡眠可以使大脑的执行功能得到部分恢复,但并不能恢复至基线水平.
목적 응용사건상관전위기술탐토8 h회복성수면대36 h완전수면박탈후대뇌집행공능적영향.방법 13명건강남성대학생삼가정상수면화36 h수면박탈량차시험,수면박탈후수시자접수8 h회복성수면.매차시험중수시자공접수6차Go/Nogo측험,동시기록행위학급ERP수거.결과 정상수면시,수시자적행위학급ERP지표재각개시간점상균무통계학차이.36 h수면박탈후,행위학지표여기선치상비유통계학차이;Fz전겁Nogo-N2、Nogo-P3급Cz전겁Nogo-P3적파폭、잠복기여기선치상비유통계학차이.8 h회복성수면후,평균정학반응시、Go정학반응솔여36 h수면박탈치상비유통계학차이;Fz전겁Nogo-N2、Nogo-P3급Cz전겁Nogo-P3적파폭여기선치상비무통계학차이,단여36 h수면박탈치상비[(-6.80±3.95)여(-3.37±2.63)μV,(10.63±6.62)여(5.63±5.45)μV,(9.49±7.37)여(6.08±6.56)μV]유통계학차이;기잠복기여기선치적차이[(254.14±15.55)여(243.08±13.97) ms,(382.14±41.07)여(349.17±30.36) ms,(369.86±26.48)여(347.48±29.24) ms]유통계학의의.결론 수면박탈손해료대뇌적집행공능,저충손해수박탈시간적연장이가중.8 h회복성수면가이사대뇌적집행공능득도부분회복,단병불능회복지기선수평.
Objective To explore the effect of recovery sleep on the executive function after 36 h of total sleep deprivation by event related potential technology.Methods Thirteen healthy male college students participated in two trials. At the first trial normal sleep as control was investigated. At the second trial participants experienced 36 h of sleep deprivation and then accepted 8 h recovery sleep. In each trial six Go/Nogo tests were employed to test the executive control function and the ERP data were recorded. Results There was no statistical difference in behavior and ERP results at each time point as the subjects had normal sleep. After 36 h of sleep deprivation, the behavior results were statistically significant when compared to the baseline. The amplitude and latency of Nogo-N2, Nogo-P3 on Fz electrode, the amplitude and latency of Nogo-P3 on Cz electrode showed statistical significance when compared to the baseline. After 8 h recovery sleep, the average correct reaction time and the Go correct reaction rate had statistical significance compared to 36 h value. The amplitude of Nogo-N2 and Nogo-P3 had no statistical significance compared to the baseline.However,it was of statistical significance[(-6.80 3.95)vs(-3.37 2.63)μV,(10.63±6.62)vs(5.63±5.45)μV,(9.49±7.37)vs(6.08±6.56)μV] compared to 36 h value. The latency of the recovery value of Nogo-N2 and Nogo-P3 was statistically significant[(254.14±15.55)vs(243.08±13.97)ms(382.14±41.07)vs(349.17±30.36)ms,(369.86±26.48)vs(347.48±29.24)ms]compared to the baseline.Conclusion As the time of sleep deprivation is prolonged, the executive function is impaired and the executive function is not completely recovered after 8 h recovery sleep.