CAJ | 학술논문

多发性骨髓瘤是骨髓内单一浆细胞株异常增生的一种恶性肿瘤,该病病程长,主要以血液中异常免疫球蛋白增多及骨质浸润破坏引起的症状多见.其皮肤表现可以分成特异性和非特异性.特异性皮损包括髓外皮肤和黏膜浆细胞瘤及多发性骨髓瘤皮肤浸润所致的皮肤肿瘤.非特异性包括由于异常的蛋白水平、细胞减少以及内脏器官受损而引起的皮肤异常改变.部分病例以皮肤损害为首发表现.熟悉上述表现,将有利于对多发性骨髓瘤更加全面的认识和较早发现.
다발성골수류시골수내단일장세포주이상증생적일충악성종류,해병병정장,주요이혈액중이상면역구단백증다급골질침윤파배인기적증상다견.기피부표현가이분성특이성화비특이성.특이성피손포괄수외피부화점막장세포류급다발성골수류피부침윤소치적피부종류.비특이성포괄유우이상적단백수평、세포감소이급내장기관수손이인기적피부이상개변.부분병례이피부손해위수발표현.숙실상술표현,장유리우대다발성골수류경가전면적인식화교조발현.
Multiple myeloma (MM) is a chronic malignancy caused by the proliferation of a single clone of plasma cells. Most of its manifestations are associated with the overexpression of abnormal immunoglobulin in blood and infiltrative destruction of bone. Cutaneous manifestations in MM are classified into specific and non-specific ones. Specific lesions include primary and secondary plasmocytoma of skin and mucosa, and non-specific lesions involve abnormal changes in skin due to the accumulation of abnormal proteins in dermoepidermal junction, cytopenia and internal organ damage. Skin lesions may be the first manifestation of MM in some cases. A familiarity with these manifestations will favor the full recognition and early diagnosis of MM.