CAJ | 학술논문

过敏性紫癜是儿童常见的自身免疫性小血管炎,其发病机制尚未完全明了.近年IgA介导的免疫学异常研究颇多,IgA沉积于受累肾小球系膜区及皮肤、肾小球、胃肠道血管壁,组织沉积原因可能涉及血清IgA产生增多、IgA特异性自身抗体异常、IgA1结构异常、IgA1受体表达异常、补体参与等,IgA的沉积介导黏附分子、细胞因子等表达异常.
과민성자전시인동상견적자신면역성소혈관염,기발병궤제상미완전명료.근년IgA개도적면역학이상연구파다,IgA침적우수루신소구계막구급피부、신소구、위장도혈관벽,조직침적원인가능섭급혈청IgA산생증다、IgA특이성자신항체이상、IgA1결구이상、IgA1수체표체이상、보체삼여등,IgA적침적개도점부분자、세포인자등표체이상.
Henoch-Schnlein purpura(HSP) is a common autoimmune small vessel vasculitis that primarily affects children.Although the pathogenesis of HSP is unknown,there are tantalizing clues on the immune abnormalities mediated by IgA,which mainly affects the vessels of the skin,gastrointestinal tract and kidneys.The reasons of deposition maybe involve in the increases of serum IgA,the abnormalities of IgA-specific autoantibodies,structures and acceptors of IgA1,complements,and so on,which mediates the abnormal expressions of adhesion molecules and cytokines.