国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2012年
4期
352-355
,共4页
微小RNA%肾发育%糖尿病肾病%肾癌%免疫相关性肾病
微小RNA%腎髮育%糖尿病腎病%腎癌%免疫相關性腎病
미소RNA%신발육%당뇨병신병%신암%면역상관성신병
MicroRNA%Kidney development%Diabetic nephropathy%Renal cell carcinoma%Immunerelated nephropathy
microRNA(miRNA)是一种广泛存在于各种生物体内非编码的内源性RNA产物,具有在转录后水平调控基因表达的能力.研究发现,这种内源性的miRNA在细胞增殖、分化、凋亡以及疾病免疫炎症反应中发挥着重要作用,估计人体中有近1/3的基因都由miRNA调控.近年来miRNA在肾脏生理、病理相关机制中的研究逐渐增多和深入,现对其在肾脏疾病中的研究进展作一综述.
microRNA(miRNA)是一種廣汎存在于各種生物體內非編碼的內源性RNA產物,具有在轉錄後水平調控基因錶達的能力.研究髮現,這種內源性的miRNA在細胞增殖、分化、凋亡以及疾病免疫炎癥反應中髮揮著重要作用,估計人體中有近1/3的基因都由miRNA調控.近年來miRNA在腎髒生理、病理相關機製中的研究逐漸增多和深入,現對其在腎髒疾病中的研究進展作一綜述.
microRNA(miRNA)시일충엄범존재우각충생물체내비편마적내원성RNA산물,구유재전록후수평조공기인표체적능력.연구발현,저충내원성적miRNA재세포증식、분화、조망이급질병면역염증반응중발휘착중요작용,고계인체중유근1/3적기인도유miRNA조공.근년래miRNA재신장생리、병리상관궤제중적연구축점증다화심입,현대기재신장질병중적연구진전작일종술.
MicroRNA (miRNA),an endogenous RNA,is wide spread in various organisms.Recent studies have found that miRNA plays an important role in cell proliferation,differentiation,apoptosis,immune and inflammatory response,etc.It's estimated that nearly 1/3 genes are regulated by miRNA.Because of its important role,the studies of miRNA related to kidney physiological and pathological mechanisms attract more attention gradually.it's very necessary to summarize the latest studies on kidney diseases.
