CAJ | 학술논문

目的分析汕头市住院肺结核患者结核分枝杆菌耐药情况.方法回顾性抽样分析2008年1月-2010年12月100例住院肺结核患者结核分枝杆菌对INH、RFP、SM和EMB的耐药性试验结果,观察初治组和复治组对抗结核药物的耐药率.结果复治组INH、RFP和EMB耐药率明显高于初治组(分别为:59.5％ vs.25.4％、40.5％ vs.7.9％和43.2％ vs.11.1％,),2组比较差异均有极显著性(P＜ 0.01)；复治组SM耐药率与初治组比较,差异无显著性(18.9％ vs.20.6％,P＞0.05).结论抗结核药物耐药性试验对肺结核患者特别是复治患者是必需的,要重新重视SM的应用.
목적 분석산두시주원폐결핵환자결핵분지간균내약정황.방법 회고성추양분석2008년1월-2010년12월100례주원폐결핵환자결핵분지간균대INH、RFP、SM화EMB적내약성시험결과,관찰초치조화복치조대항결핵약물적내약솔.결과 복치조INH、RFP화EMB내약솔명현고우초치조(분별위:59.5％ vs.25.4％、40.5％ vs.7.9％화43.2％ vs.11.1％,),2조비교차이균유겁현저성(P＜ 0.01)；복치조SM내약솔여초치조비교,차이무현저성(18.9％ vs.20.6％,P＞0.05).결론 항결핵약물내약성시험대폐결핵환자특별시복치환자시필수적,요중신중시SM적응용.
Objective To analyze resistant situation to anti-TB drugs of mycobacterium tuberculosis among inpatients with pulmonary tuberculosis in the Third People's Hospital of Shantou.Methods The retrospective sampling analysis was conducted on drug resistant tests to IN H,RFP,SM and EMB of mycobacterium tuberculosis among 100 inpatients from Jan 1,2008 to Dec 31,2010.The drug resistance rate of new treatment group and re-treatment group were observed.Results The drug resistance rate of INH,RFP and EMB of re-treatment group were significantly higher than those of new treatment group ( 59.5％ vs 25.4％,40.5％ vs 7.9％ and 43.2％ vs 11.1％,all P ＜ 0.01 ); The drug resistance rate of SM were 18.9％ in the re-treatment group and 20.6％ in the new treatment group,the difference between the two groups were not statistically significant ( P ＞ 0.05 ).Conclusions The drug resistant tests of anti-TB drugs were necessary to the patients with pulmonary tuberculosis especially in re-treatment patients,and the use of SM should be caused to attention.