CAJ | 학술논문

目的探讨腹腔镜胆总管切开探查术对机体免疫功能的影响.方法将可手术治疗的胆总管结石患者50例随机分为腹腔镜手术组(腹腔镜组)和开放手术组(开腹组)各25例.于术前和术后1、3、5 d测定T淋巴细胞亚群、C反应蛋白(CRP)、白介素6(IL-6)、免疫球蛋白IgG.结果两组术后CD_3~+、CD_4~+、CD_4~+/CD_8~+均明显下降(P<0.05),且开腹组明显低于腹腔镜组(P<0.05).CRP、IL_6均较术前明显升高(P<0.05),且开腹组明显高于腹腔镜组(P<0.05).两组患者免疫球蛋白IgG术前、术后均无明显变化(P>0.05).结论腹腔镜胆总管切开探查术与开腹手术相比较,对机体免疫功能的影响相对较小.
목적 탐토복강경담총관절개탐사술대궤체면역공능적영향.방법 장가수술치료적담총관결석환자50례수궤분위복강경수술조(복강경조)화개방수술조(개복조)각25례.우술전화술후1、3、5 d측정T림파세포아군、C반응단백(CRP)、백개소6(IL-6)、면역구단백IgG.결과 량조술후CD_3~+、CD_4~+、CD_4~+/CD_8~+균명현하강(P<0.05),차개복조명현저우복강경조(P<0.05).CRP、IL_6균교술전명현승고(P<0.05),차개복조명현고우복강경조(P<0.05).량조환자면역구단백IgG술전、술후균무명현변화(P>0.05).결론 복강경담총관절개탐사술여개복수술상비교,대궤체면역공능적영향상대교소.
Objective To study the effect of lapaxoscopic common bile duet exploration on systemic immune function.Methods 50 pafiems with comnlon bile duct stone were assigned to laparoscopy-assisted group and conven-tional open abdominal group,with 25 cases in each group.Pefiphend venous blood samples were taken to determine the levels of T lymphocyte subpopulation,CRP,IL-6,IgG preoperafion and postoperation 1,3,5d,respectively.Results The levels of CD_3~+ cells,CD_4~+,cells,CD_4~+/CD_8~+ were significantly decreased after operation in both groups(p<0.05),and the change in the open abdominal group Was obviously higher than that in the laparoscepy-assisted group.There was a significant difference between twogroups(P<0.05).The levels of CIIP,IL-6 were significantly increased after operation in both groups(P<0.05),and the change in the open abdominal group Was obviously higher than that in the laparoscopy-assisted group.There Was significant difference between two groups(P<0.05).IgG had no change at preopemfion and postoperation in both groups(P>0.05).Conclusion The results showed that laparoscopic com-mon bile duct exploration exerts less effects on systemic immune function than that of conventional open abdominal op-elation.