CAJ | 학술논문

目的评价CT引导下经皮肺穿刺冷循环射频消融(RFA)治疗晚期肺癌的有效性和安全性.方法对32例102个不同病理类型的晚期肺癌病灶行冷循环RFA治疗,观察治疗过程中患者血压、脉搏和周围血氧饱和度的变化;治疗前后肝肾、肺功能的改变以及CT扫描肿瘤体积的变化.结果 32例晚期肺癌患者冷循环RFA治疗中血压、脉搏及周围血氧饱和度无明显改变;治疗后肝肾功能、肺功能无明显影响;治疗后1个月内CT扫描见肿瘤体积较术前有所增大,3个月后102个肿瘤中,肿瘤完全消失(CR)23个,肿瘤缩小80%～100%(Pra)53个,缩小50%～80%(PRb)24个,缩小不足50%(NR)2个.结论冷循环RFA治疗晚期肺癌创伤小,近期疗效好,比较安全,可能为临床提供了一种新的安全有效的治疗方法.
목적 평개CT인도하경피폐천자랭순배사빈소융(RFA)치료만기폐암적유효성화안전성.방법 대32례102개불동병리류형적만기폐암병조행랭순배RFA치료,관찰치료과정중환자혈압、맥박화주위혈양포화도적변화;치료전후간신、폐공능적개변이급CT소묘종류체적적변화.결과 32례만기폐암환자랭순배RFA치료중혈압、맥박급주위혈양포화도무명현개변;치료후간신공능、폐공능무명현영향;치료후1개월내CT소묘견종류체적교술전유소증대,3개월후102개종류중,종류완전소실(CR)23개,종류축소80%～100%(Pra)53개,축소50%～80%(PRb)24개,축소불족50%(NR)2개.결론 랭순배RFA치료만기폐암창상소,근기료효호,비교안전,가능위림상제공료일충신적안전유효적치료방법.
Objective To investigate the efficacy and safety of percutaneous Cool-tip Radiofrequency ablation guided by computerized tomography (CT) for the treatment of advanced lung cancer. Methods 32 patients of advanced lung cancer with 102 different pathological types were treated with MERP technique. The patients' blood pressure,pulse rate and oxygen saturation were monitored during the procedure. The hepatic, pulmonary and renal functions were examined before and after the procedure. The tumor bulk was compared with CT before and after the treatment. Results There were no any changes in the blood pressure, pulse rate and oxygen saturation in the whole series before, immediately after the term ination and one month after the procedure, nor did the hepatic,pulmonary and renal function as well. The bulk of the tumor in this group as a whole enlarged by the end of the first month after the therapy. The CT scanning of the tumor at the end of the third month revealed that there had 23 CR, 53 PRa, 24 PRb, and 2 NR among 102 tumors. Conclusion The Cool-tip Radiofrequency ablation is a promising mini-invasive technique for the treatment of advanced lung cancer with the satisfactory efficacy and safety.