中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2004年
6期
1188-1189
,共2页
钙化合物%铝代谢%铅代谢%吸收%大鼠
鈣化閤物%鋁代謝%鉛代謝%吸收%大鼠
개화합물%려대사%연대사%흡수%대서
目的:探讨不同钙化合物对大鼠铝、铅代谢的影响. 方法:将幼年 Sprague-Dawley大鼠 30只(雌雄性各半),分成柠檬酸钙+铝+铅组、醋酸钙+铝+铅组和碳酸钙+铝+铅组等 3组.各组动物分别用不同形式的钙化合物通过灌胃给予等剂量钙元素,共 4周.实验结束后,用电感耦合等离子体原子发射光谱法( ICP-AES)分别测定全血、肝、肾、股骨和大脑中铝和铅的含量. 结果:醋酸钙组、柠檬酸钙组和碳酸钙组铅的表观吸收率分别为(- 29.97± 28.85)%,(- 86.20± 87.60)%和(- 163.56± 93.77)%;大脑中铝浓度分别为( 3.84± 1.49),( 3.67± 1.31)和( 0.83± 1.61) μ g/g.大鼠摄入醋酸钙和柠檬酸钙后对铅的表观吸收率要高于碳酸钙组的大鼠( F=- 23.744,7.802,P< 0.05).摄入柠檬酸钙和醋酸钙的大鼠的大脑和骨骼组织中铝和铅水平高于摄入碳酸钙的大鼠 (F=12.411～ 38.333,P< 0.05). 结论:长期摄入柠檬酸钙和醋酸钙有增加铅吸收的危险,并可使铅和铝蓄积在骨骼和大脑.
目的:探討不同鈣化閤物對大鼠鋁、鉛代謝的影響. 方法:將幼年 Sprague-Dawley大鼠 30隻(雌雄性各半),分成檸檬痠鈣+鋁+鉛組、醋痠鈣+鋁+鉛組和碳痠鈣+鋁+鉛組等 3組.各組動物分彆用不同形式的鈣化閤物通過灌胃給予等劑量鈣元素,共 4週.實驗結束後,用電感耦閤等離子體原子髮射光譜法( ICP-AES)分彆測定全血、肝、腎、股骨和大腦中鋁和鉛的含量. 結果:醋痠鈣組、檸檬痠鈣組和碳痠鈣組鉛的錶觀吸收率分彆為(- 29.97± 28.85)%,(- 86.20± 87.60)%和(- 163.56± 93.77)%;大腦中鋁濃度分彆為( 3.84± 1.49),( 3.67± 1.31)和( 0.83± 1.61) μ g/g.大鼠攝入醋痠鈣和檸檬痠鈣後對鉛的錶觀吸收率要高于碳痠鈣組的大鼠( F=- 23.744,7.802,P< 0.05).攝入檸檬痠鈣和醋痠鈣的大鼠的大腦和骨骼組織中鋁和鉛水平高于攝入碳痠鈣的大鼠 (F=12.411～ 38.333,P< 0.05). 結論:長期攝入檸檬痠鈣和醋痠鈣有增加鉛吸收的危險,併可使鉛和鋁蓄積在骨骼和大腦.
목적:탐토불동개화합물대대서려、연대사적영향. 방법:장유년 Sprague-Dawley대서 30지(자웅성각반),분성저몽산개+려+연조、작산개+려+연조화탄산개+려+연조등 3조.각조동물분별용불동형식적개화합물통과관위급여등제량개원소,공 4주.실험결속후,용전감우합등리자체원자발사광보법( ICP-AES)분별측정전혈、간、신、고골화대뇌중려화연적함량. 결과:작산개조、저몽산개조화탄산개조연적표관흡수솔분별위(- 29.97± 28.85)%,(- 86.20± 87.60)%화(- 163.56± 93.77)%;대뇌중려농도분별위( 3.84± 1.49),( 3.67± 1.31)화( 0.83± 1.61) μ g/g.대서섭입작산개화저몽산개후대연적표관흡수솔요고우탄산개조적대서( F=- 23.744,7.802,P< 0.05).섭입저몽산개화작산개적대서적대뇌화골격조직중려화연수평고우섭입탄산개적대서 (F=12.411～ 38.333,P< 0.05). 결론:장기섭입저몽산개화작산개유증가연흡수적위험,병가사연화려축적재골격화대뇌.
AIM: To explore the effects of different calcium compounds on aluminum(Al) and lead(Pb) metabolism in rats. METHODS: Thirty young rats(15 male and 15 female),were divided into three groups: Ca-citrate+ Al+ Pb group,Ca-acetate+ Al+ Pb group,and Ca-carbonate+ Al+ Pb group.The rats of each group were given calcium element of the same dosage by gavage of various calcium compounds for four weeks.After the experiment,Al and Pb levels in whole blood,liver,kidney, femur and cerebrum were measured by ICP-AES. RESULTS:In the Ca-acetate+ Al+ Pb group,Ca-citrate+ Al+ Pb group and Ca-carbonate+ Al+ Pb group,the apparent absorptivity of Pb(- 29.97± 28.85)% ,(- 86.20± 87.60)% and(- 163.56± 93.77)%; concentration of Al in cerebrum: (3.84± 1.49),(3.67± 1.31) and (0.83± 1.61)μ g/g.The absorptivities of Pb in the rats treated with calcium citrate and calcium acetate were higher than those treated with calcium carbonate.The aluminum and lead levels in the cerebrum and bone in the rats treated with calcium citrate and calcium acetate were higher than those treated with calcium carbonate. CONCLUSION:Long-term ingestion of Ca-acetate and Ca-citrate presents a risk of enhancing Al and Pb absorption and making them retained in the cerebrum and bone.
