CAJ | 학술논문

目的研究丹红注射液联合甲钴胺注射液对糖尿病周围神经病变(DPN)的临床疗效.方法将符合1999年ADA标准诊断为2型糖尿病的72例患者随机分为治疗组和对照组,治疗组静脉滴注丹红注射液,20ml/d,同时肌肉注射甲钴胺注射液500 μg/d;对照组仅肌肉注射甲钴胺注射液.2周后观察其临床疗效及测定运动神经传导速度(MNCV)、感觉神经传导速度(SNCV).结果治疗组患者临床总有效率92.1%;对照组总有效率67.6%,两组比较有显著性差异(P＜0.01).治疗组治疗前后SNCV、MNCV均有显著性差异(P＜0.01);治疗后两组比较有显著性差异(P＜0.05),两组均无明显的不良反应.结论丹红注射液与甲钴胺注射液联合应用优于单独应用甲钴胺注射液对DPN的治疗效果.
목적 연구단홍주사액연합갑고알주사액대당뇨병주위신경병변(DPN)적림상료효.방법 장부합1999년ADA표준진단위2형당뇨병적72례환자수궤분위치료조화대조조,치료조정맥적주단홍주사액,20ml/d,동시기육주사갑고알주사액500 μg/d;대조조부기육주사갑고알주사액.2주후관찰기림상료효급측정운동신경전도속도(MNCV)、감각신경전도속도(SNCV).결과 치료조환자림상총유효솔92.1%;대조조총유효솔67.6%,량조비교유현저성차이(P＜0.01).치료조치료전후SNCV、MNCV균유현저성차이(P＜0.01);치료후량조비교유현저성차이(P＜0.05),량조균무명현적불량반응.결론 단홍주사액여갑고알주사액연합응용우우단독응용갑고알주사액대DPN적치료효과.
Objective To evaluate the clinical efficacy of Dan-Hong Injection and Methycobal combined therapy in treating diabetic peripheral neuropathy(DPN).Methods 72 cases of peripheral neuropathy and type 2 diabetes(conformed to ADA standard published in 1999)were randomly separated into an experimem group and a control group.Members in the experiment group were treated with Dan-Hong injection 20ml/day i.v.and Methycobal 500ug/day i.m.Members in the control group were treated with Methycobal only.At the end of 2 weeks'therapeutic courses,motor nerve conducdon velocity (MNCV)and sural nerve conduction velocity(SNCV)were evaluated.Results The overall effective rate was 92.1% in the experiment group and 67.6% in the control group,showing significant difference between the two groups(P＜0.01).The post-therapeutic values of both SNCV and MNCV were significantly different from those of previous treatment.(P＜0.01)The post-therapeutic values of SNCV and MNCV of the experiment group were also significantly different from those of the control group(P＜0.05).No evidently relative adverse effects were observed in both groups.Conclusions Combined therapy of Dan-Hong injection and Methycobal was more effective in controlling the clinical activity of diabetic peripheral neuropathy.