CAJ | 학술논문

目的分析缺血性卒中患者血清前白蛋白水平与疾病严重程度的关系.方法选择2000年至2008年在北京协和医院住院治疗的缺血性卒中患者2522例,回顾性分析临床资料.采用改良Rankin评分(mRS)评定患者入院时神经功能缺损程度,将患者分为轻度神经功能缺损组(mRS≤3)和重度神经功能缺损组(mRS ＞3).在患者入院后24 h内测定血清前白蛋白和超敏C反应蛋白水平,比较两组间血清前白蛋白和超敏C反应蛋白水平差异,并分析血清前白蛋白水平与超敏C反应蛋白之间的关系.以P＜0.05为差异有统计学意义.结果轻度神经功能缺损组共1697例患者,平均mRS为1.67分,重度神经功能缺损组共825例患者,平均mRS为4.53分.轻度神经功能缺损组血清前白蛋白水平为219.18 mg/L,四分位距为72.00 mg/L,重度神经功能缺损组分别为191.20 mg/L和82.00 mg/L.轻度神经功能缺损组超敏C反应蛋白水平为4.15 mg/L,四分位距6.93 mg/L,重度神经功能缺损组分别为6.01 mg/L和8.22 mg/L.两组间血清前白蛋白(P =0.000)和超敏C反应蛋白水平(P =0.000)的差异均具有统计学意义.神经功能缺失程度与血清前白蛋白水平呈负相关关系(r=-0.115,P=0.000),与超敏C反应蛋白呈正相关(r=0.098,P=0.000),血清前白蛋白水平与超敏C反应蛋白负相关(r=-0.396,P=0.000).结论血清前白蛋白水平与疾病严重程度及炎性反应程度有关.
목적 분석결혈성졸중환자혈청전백단백수평여질병엄중정도적관계.방법 선택2000년지2008년재북경협화의원주원치료적결혈성졸중환자2522례,회고성분석림상자료.채용개량Rankin평분(mRS)평정환자입원시신경공능결손정도,장환자분위경도신경공능결손조(mRS≤3)화중도신경공능결손조(mRS ＞3).재환자입원후24 h내측정혈청전백단백화초민C반응단백수평,비교량조간혈청전백단백화초민C반응단백수평차이,병분석혈청전백단백수평여초민C반응단백지간적관계.이P＜0.05위차이유통계학의의.결과 경도신경공능결손조공1697례환자,평균mRS위1.67분,중도신경공능결손조공825례환자,평균mRS위4.53분.경도신경공능결손조혈청전백단백수평위219.18 mg/L,사분위거위72.00 mg/L,중도신경공능결손조분별위191.20 mg/L화82.00 mg/L.경도신경공능결손조초민C반응단백수평위4.15 mg/L,사분위거6.93 mg/L,중도신경공능결손조분별위6.01 mg/L화8.22 mg/L.량조간혈청전백단백(P =0.000)화초민C반응단백수평(P =0.000)적차이균구유통계학의의.신경공능결실정도여혈청전백단백수평정부상관관계(r=-0.115,P=0.000),여초민C반응단백정정상관(r=0.098,P=0.000),혈청전백단백수평여초민C반응단백부상관(r=-0.396,P=0.000).결론 혈청전백단백수평여질병엄중정도급염성반응정도유관.
Objective To assess the relationship of serum prealbumin level with the severity of acute ischemic stroke (AIS).Methods The clinical data of 2522 AIS patients who were admitted in Peking Union Medical College Hospital from 2000 to 2008 were retrospectively analyzed.The serum prealbumin and hypersensitive C-reactive protein (hs-CRP) levels were evaluated by immunoturbidimetric assay within 24 hours after admission.The AIS severity was evaluated at admission using modified Rankin Scale (mRS).Patients were divided into mild AIS group (mRS score ≤ 3 ) and severe AIS group (mRS score ＞ 3 ).The levels of serum prealbumin and hs-CRP were compared between these two groups,and the relationship between praalbumin and hs-CRP was also analyzed.Results There were 1697 patients in the mild group (average mRS score:1.67) and 825 patients in the severe group ( average mRS score:4.53 ).The severe group had significantly lower prealbumin level [ ( 191.20,82.00)versus (219.18,72.00) mg/L,P =0.000] and higher hs-CRP level [ (6.01,8.22) versus (4.15,6.93) mg/L,P =0.000 ] than the mild group,respectively.Partial regression analysis showed that the stroke severity was negatively correlated with serum prealbumin level (r =-0.115,P =0.000) and positively correlated with hs-CRP level (r =0.098,P =0.000).Serum prealbumin level was inversely correlated with hs-CRP level ( r =- 0.396,P =0.000).Conclusion The prealbumin level is relevant with the severity of AIS and inflammation.