CAJ | 학술논문

目的制备大黄素传递体,并建立其有关质量评价标准.方法采用薄膜超声法制备大黄素传递体,以包封率为考察指标,通过单因素考察和正交实验设计优选最佳处方和工艺；采用Zetasizer电位及纳米粒度分析仪测定其Zeta电位并分析其大小,用紫外分光光度法测定药物的包封率等.结果大黄素传递体最佳制备配方为去氧胆酸钠与磷脂比为1∶8,胆固醇与磷脂比为1∶3,维生素E与磷脂比为1∶20,大黄素与磷脂比为1∶6.所得大黄素传递体Zeta电位-15.11 mV,平均粒径为292.2 nm,球形圆整,大小均匀.在检测波长为435 nm处的吸光度(A)与药物浓度[C,(g/L)]的标准曲线方程为A=50.485C -0.0913(R2=0.9991),测得平均包封率为(69.35 ±0.25)％.结论该传递体制备处方精确合理、工艺简单可行,所得传递体带负电,粒径较小且分布均匀,包封率高且稳定性好.
목적 제비대황소전체체,병건립기유관질량평개표준.방법 채용박막초성법제비대황소전체체,이포봉솔위고찰지표,통과단인소고찰화정교실험설계우선최가처방화공예；채용Zetasizer전위급납미립도분석의측정기Zeta전위병분석기대소,용자외분광광도법측정약물적포봉솔등.결과 대황소전체체최가제비배방위거양담산납여린지비위1∶8,담고순여린지비위1∶3,유생소E여린지비위1∶20,대황소여린지비위1∶6.소득대황소전체체Zeta전위-15.11 mV,평균립경위292.2 nm,구형원정,대소균균.재검측파장위435 nm처적흡광도(A)여약물농도[C,(g/L)]적표준곡선방정위A=50.485C -0.0913(R2=0.9991),측득평균포봉솔위(69.35 ±0.25)％.결론 해전체체제비처방정학합리、공예간단가행,소득전체체대부전,립경교소차분포균균,포봉솔고차은정성호.
Objective To prepare the emodin transfersome and to evaluate its quality.Methods Emodin transfersome was prepared by film-ultrasonic dispersion method.The effects of the ratio of different components in the transfersome products on encapsulation efficiency were investigated.The rates of envelopment of emodin transfersome were determined by ultraviolet spectrophotometry(UV).The particle size and Zeta potential of emodin transfersome were evaluated by Zetasizer analyzer.Results The appropriate formulation was cholesterol vs phospholipids 1 ∶ 3,deoxycholic acid sodium salt vs phospholipids 1∶ 6,emodin vs phospholipids 1∶ 10,vitamin E vs phospholipids 1∶ 20.Zeta potential was-15.11 mV and the particle size was 292.2 nm.The mean encapsulation efficiency was(65.35 ±0.25) ％.Conclusion The preparation method is simple and reasonable,showing high encapsulation efficiency and stability.