国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
11期
843-845
,共3页
慢性阻塞性肺疾病%氧摄取率
慢性阻塞性肺疾病%氧攝取率
만성조새성폐질병%양섭취솔
Chronic obstructive pulmonary disease%Oxygen extraction fraction
目的 探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者外周组织氧摄取率(O2ER)及变化情况.方法 所有符合条件患者分两组(单纯AECOPD组14例,AECOPD合并呼吸衰竭和肺源性心脏病组24例),分别于人院后第1天、第3天和第7天(或出院时)卧床休息,停止吸氧30 min后分别同时抽桡动脉及肘静脉血行血气分析并计算出O2ER.应用统计学方法分别比较两组患者外周O2ER动态改变以及O2ER与呼吸闲难评分、出院时第1秒用力呼气容积(FEV1)的相关性.结果 ①单纯AECOPD组患者病情稳定后外周O2ER显著下降(P<0.01),而合并呼吸功能衰竭和肺源性心脏病组患者外周O2ER变化动态改变差异无统计学意义(P>0.05);②两组患者在入院时及入院第3天外周O2ER差异无统计学意义,出院时单纯AECOPD组外周O2ER较合并呼吸功能衰竭肺源性心脏病组显著降低(P<0.01);③两组患者在第1天和第3天外周O2ER与呼吸困难评分及FEV1均无相关性(P>0.05),病情稳定及出院时外周O2ER与呼吸困难评分呈正相关,(r=0.365,P=0.024),与FEV1呈负相关(r=0.342,P＜0.05).结论 ①单纯AECOPD组患者病情稳定后外周O2ER较急性期或AECOPD合并呼吸功能衰竭和肺源性心脏病组患者下降;②AECOPD患者病情稳定及出院时外周O2ER与呼吸困难评分呈正相关,与FEV1呈负相关.
目的 探討慢性阻塞性肺疾病急性加重期(AECOPD)患者外週組織氧攝取率(O2ER)及變化情況.方法 所有符閤條件患者分兩組(單純AECOPD組14例,AECOPD閤併呼吸衰竭和肺源性心髒病組24例),分彆于人院後第1天、第3天和第7天(或齣院時)臥床休息,停止吸氧30 min後分彆同時抽橈動脈及肘靜脈血行血氣分析併計算齣O2ER.應用統計學方法分彆比較兩組患者外週O2ER動態改變以及O2ER與呼吸閒難評分、齣院時第1秒用力呼氣容積(FEV1)的相關性.結果 ①單純AECOPD組患者病情穩定後外週O2ER顯著下降(P<0.01),而閤併呼吸功能衰竭和肺源性心髒病組患者外週O2ER變化動態改變差異無統計學意義(P>0.05);②兩組患者在入院時及入院第3天外週O2ER差異無統計學意義,齣院時單純AECOPD組外週O2ER較閤併呼吸功能衰竭肺源性心髒病組顯著降低(P<0.01);③兩組患者在第1天和第3天外週O2ER與呼吸睏難評分及FEV1均無相關性(P>0.05),病情穩定及齣院時外週O2ER與呼吸睏難評分呈正相關,(r=0.365,P=0.024),與FEV1呈負相關(r=0.342,P＜0.05).結論 ①單純AECOPD組患者病情穩定後外週O2ER較急性期或AECOPD閤併呼吸功能衰竭和肺源性心髒病組患者下降;②AECOPD患者病情穩定及齣院時外週O2ER與呼吸睏難評分呈正相關,與FEV1呈負相關.
목적 탐토만성조새성폐질병급성가중기(AECOPD)환자외주조직양섭취솔(O2ER)급변화정황.방법 소유부합조건환자분량조(단순AECOPD조14례,AECOPD합병호흡쇠갈화폐원성심장병조24례),분별우인원후제1천、제3천화제7천(혹출원시)와상휴식,정지흡양30 min후분별동시추뇨동맥급주정맥혈행혈기분석병계산출O2ER.응용통계학방법분별비교량조환자외주O2ER동태개변이급O2ER여호흡한난평분、출원시제1초용력호기용적(FEV1)적상관성.결과 ①단순AECOPD조환자병정은정후외주O2ER현저하강(P<0.01),이합병호흡공능쇠갈화폐원성심장병조환자외주O2ER변화동태개변차이무통계학의의(P>0.05);②량조환자재입원시급입원제3천외주O2ER차이무통계학의의,출원시단순AECOPD조외주O2ER교합병호흡공능쇠갈폐원성심장병조현저강저(P<0.01);③량조환자재제1천화제3천외주O2ER여호흡곤난평분급FEV1균무상관성(P>0.05),병정은정급출원시외주O2ER여호흡곤난평분정정상관,(r=0.365,P=0.024),여FEV1정부상관(r=0.342,P＜0.05).결론 ①단순AECOPD조환자병정은정후외주O2ER교급성기혹AECOPD합병호흡공능쇠갈화폐원성심장병조환자하강;②AECOPD환자병정은정급출원시외주O2ER여호흡곤난평분정정상관,여FEV1정부상관.
Objective To explore the O2ER and its change of peripheral tissues in AECOPD patients. Methods All the enrolled patients were divided into two groups (14 cases in the single AECOPD group and 24 cases in the AECOPD+RF+PHD group) to complete bed rest separately at 1 d, 3 d and 7 d (or at discharge) after admission, and the radial arterial and ulnar venous blood was collected at 30 min after discontinuation of oxygen inhalation for blood gas analysis and calculation of O2 ER. The statistical methods were used for comparison in the dynamic change of peripheral O2ER between two groups, as well as in the correlation among O2ER, dyspnea score and FEV1 at discharge. Results ①The peripheral O2ER was significantly decreased in the single AECOPD group after the condition became table (P<0.01),while there was no statistical significance for the dynamic change of peripheral O2ER in the AECOPD+RF+PHD group (P > 0. 05). ②No statistical significance was identified for the difference in the peripheral O2ER between two groups at admission and 3 d after admission, but it was obviously decreased in the single AECOPD group at discharge compared with the AECOPD+RF+PHD group ( P <0. 01).③In the two groups, the peripheral O2ER was not associated with dyspnea score and FEV, at 1 d and 3 d(P>0.05), but positively correlated to dyspnea score ( r =0.365, P =0.024) and negatively correlated to FEV1 ( r =0.342, P<0.05) after the condition was stable and at discharge. Conclusions ①Compared with the acute stage or the AECOPD+RF+PHD group, the peripheral O2ER in the single AECOPD group was decreased after the condition became stable. ②After the condition was stable and at discharge,the peripheral O2ER in AECOPD patients was positively correlated to dyspnea score and negatively correlated to FEV1.
