CAJ | 학술논문

目的探讨芪穹胶囊(QQJN)对局部脑缺血再灌注损伤的保护作用及其机制。方法采用大鼠线栓法制备局脑缺血再灌注模型，观察QQJN对神经功能评分、脑梗死百分比、脑组织病理形态学、脑组织SOD活性、MDA含量、体外血栓形成及血小板聚集的影响。结果与模型组比较，QQJN(4.4、8.8g/kg)对脑缺血再灌注8h和22h的神经功能评分有一定的降低作用，可以减少脑梗死百分比，不同程度的改善脑组织病理形态学的变化；QQJN(4.4、8.8 g/kg)可以增加脑组织SOD活性，降低MDA含量，具有抑制体外血栓形成和血小板聚集等作用。结论 QQJN对局脑缺血再灌注损伤具有一定的保护作用，其机制可能与抗自由基损伤、抑制血小板聚集、血栓形成等有关。
목적 탐토기궁효낭(QQJN)대국부뇌결혈재관주손상적보호작용급기궤제。방법 채용대서선전법제비국뇌결혈재관주모형，관찰QQJN대신경공능평분、뇌경사백분비、뇌조직병리형태학、뇌조직SOD활성、MDA함량、체외혈전형성급혈소판취집적영향。결과 여모형조비교，QQJN(4.4、8.8g/kg)대뇌결혈재관주8h화22h적신경공능평분유일정적강저작용，가이감소뇌경사백분비，불동정도적개선뇌조직병리형태학적변화；QQJN(4.4、8.8 g/kg)가이증가뇌조직SOD활성，강저MDA함량，구유억제체외혈전형성화혈소판취집등작용。결론 QQJN대국뇌결혈재관주손상구유일정적보호작용，기궤제가능여항자유기손상、억제혈소판취집、혈전형성등유관。
Objective To study the protective effects of Qiqiong(QQJN) on focal cerebral ischemia/reperfusion injury and its mechanism. Methods Middle cerebral artery occlusion(MCAO) was used to make focal cerebral ischemia/reperfusion model by intravascular nylon filament occlusion. The protective effects of QQJN were evaluated by investigating neurological function score, percentage of cerebral infarction, pathomorphology of brain, the activity of SOD and the content of MDA in hrain tissue,thrombogenesis and platelet aggregation in vitro. Results Compared with model group, QQJN(4.4、8.8g/kg)could decrease the neurological score in 8 and 22h after reperfusion, reduce the percentage of cerebral infauction,improve pathomorphology of brain, decrease the length, wet weight and dry weight of thromb and inhibit platelet aggregation. Conclusion QQJN had protective effects on focal cerebral ischemia/reperfusion injury. The role of anti-injury of free radicals,inhibit thrombogenesis and platelet aggregation should contribute to its neuroprotective effects.